Results 1 to 10 of about 355,752 (283)

The MocR/GabR Ectoine and Hydroxyectoine Catabolism Regulator EnuR: Inducer and DNA Binding

Frontiers in Microbiology, 2021
The compatible solutes ectoine and 5-hydroxyectoine are widely synthesized by bacteria as osmostress protectants. These nitrogen-rich tetrahydropyrimidines can also be exploited as nutrients by microorganisms. Many ectoine/5-hydroxyectoine catabolic gene
Lucas Hermann, Lucas Hermann, Felix Dempwolff, Wieland Steinchen, Sven-Andreas Freibert, Sander H. J. Smits, Sander H. J. Smits, Andreas Seubert, Erhard Bremer, Erhard Bremer   +9 more
doaj   +1 more source

Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000 Pseudomonas aeruginosa Genomes

Microorganisms, 2023
Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the pathogen Pseudomonas aeruginosa. Changes in their DNA binding regions, i.e., palindromic operators, can compromise pump depression and subsequently enhance ...
María Pérez-Vázquez, Carla López-Causapé, Andrés Corral-Lugo, Michael J. McConnell, Jesús Oteo-Iglesias, Antonio Oliver, Antonio J. Martín-Galiano   +6 more
doaj   +1 more source

Insertion of 643bp Retrotransposon Upstream of PPARγ CDS Is Associated with Backfat of Large White Pigs

Animals, 2023
PPARs are essential regulators of mammalian fatty acid and lipid metabolism. Although the effects of genetic variations, including single nucleotide polymorphisms (SNPs) in PPARs genes on the phenotype of domestic animals have been investigated, there is
Jia He, Miao Yu, Chenglin Chi, Zhanyu Du, Yao Zheng, Cai Chen, Ali Shoaib Moawad, Chengyi Song, Xiaoyan Wang   +8 more
doaj   +1 more source

Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease [PDF]

International Neurourology Journal, 2022
Purpose Deregulation of SNCA encoding α-synuclein (α-SYN) has been associated with both the familial and sporadic forms of Parkinson disease (PD). Epigenetic regulation plays a crucial role in PD.
Subhrangshu Guhathakurta, Min Kyung Song, Sambuddha Basu, Goun Je, Ana Clara Cristovao, Yoon-Seong Kim   +5 more
doaj   +1 more source

MrMYB6 From Chinese Bayberry (Myrica rubra) Negatively Regulates Anthocyanin and Proanthocyanidin Accumulation

Frontiers in Plant Science, 2021
Anthocyanins and proanthocyanidins (PAs) are important flavonoids in Chinese bayberry (Morella rubra), which functions in fruit color and exhibits multiple health promoting and disease-preventing effects.
Liyu Shi, Xin Chen, Kang Wang, Minjie Yang, Wei Chen, Zhenfeng Yang, Shifeng Cao   +6 more
doaj   +1 more source

Identification of Promoter Region Markers Associated With Altered Expression of Resistance-Nodulation-Division Antibiotic Efflux Pumps in Acinetobacter baumannii

Frontiers in Microbiology, 2022
Genetic alterations leading to the constitutive upregulation of specific efflux pumps contribute to antibacterial resistance in multidrug resistant bacteria.
Mireia López-Siles, Michael J. McConnell, Antonio J. Martín-Galiano   +2 more
doaj   +1 more source

Rules of Expansion: an Updated Consensus Operator Site for the CopR-CopY Family of Bacterial Copper Exporter System Repressors

mSphere, 2020
Copper is broadly toxic to bacteria. As such, bacteria have evolved specialized copper export systems (cop operons) often consisting of a DNA-binding/copper-responsive regulator (which can be a repressor or activator), a copper chaperone, and a copper ...
Henrik O’Brien, Joseph W. Alvin, Sanjay V. Menghani, Yamil Sanchez-Rosario, Koenraad Van Doorslaer, Michael D. L. Johnson   +5 more
doaj   +1 more source

Conserved and Unique Functions of Blimp1 in Immune Cells

Frontiers in Immunology, 2022
B-lymphocyte-induced maturation protein-1 (Blimp1), is an evolutionarily conserved transcriptional regulator originally described as a repressor of gene transcription.
Samantha Nadeau, Samantha Nadeau, Gislâine A. Martins, Gislâine A. Martins, Gislâine A. Martins   +4 more
doaj   +1 more source

Biophysical and Biochemical Characterization of the Binding of the MarR-like Transcriptional Regulator Saro_0803 to the nov1 Promotor and Its Inhibition by Resveratrol

Biomolecules, 2023
Saro_0803 is a transcriptional factor modulating the transcription of the stilbene-degrading enzyme gene nov1 in Novosphingobium aromaticivorans DSM 12444.
Zhen He, Zunhui Ke, Wei Wang, Yahui Liu, Haoran Zhang, Yan Li   +5 more
doaj   +1 more source

A Gain-of-Function Mutant of IAA15 Inhibits Lateral Root Development by Transcriptional Repression of LBD Genes in Arabidopsis

Frontiers in Plant Science, 2020
Lateral root development is known to be regulated by Aux/IAA-ARF modules in Arabidopsisthaliana. As components, several Aux/IAAs have participated in these Aux/IAA-ARF modules.
Sun Ho Kim, Sunghwa Bahk, Jonguk An, Shah Hussain, Nhan Thi Nguyen, Huy Loc Do, Jae-Yean Kim, Jong Chan Hong, Woo Sik Chung   +8 more
doaj   +1 more source