Results 1 to 10 of about 332,136 (254)

Finding the center reliably: robust patterns of developmental gene expression [PDF]

Phys. Rev. Lett. 95, 208103 (2005), 2005
We investigate a mechanism for the robust identification of the center of a developing biological system. We assume the existence of two morphogen gradients, an activator emanating from the anterior, and a co-repressor from the posterior. The co-repressor inhibits the action of the activator in switching on target genes.
A. Eldar, A. M. Turing, A. V. Spirov, B. Houchmandzadeh, C. Zhao, H. Meinhardt, L. Wolpert, Martin Howard, Pieter Rein ten Wolde, X. Ma   +9 more
arxiv   +3 more sources

Concentration and Length Dependence of DNA Looping in Transcriptional Regulation [PDF]

, 2008
In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest. This action at a distance is often mediated by the formation of DNA loops: Binding at two or more sites on the DNA results in the formation of a loop, which can bring the ...
Beausang, John F., Blumberg, Seth, Garcia, Hernan G., Han, Lin, Nelson, Philip C., Phillips, Rob, Towles, Kevin B.   +6 more
arxiv   +15 more sources

Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression [PDF]

Phys. Rev. E 95, 042412 (2017), 2016
Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters.
Lengyel, Iván M., Morelli, Luis G.
arxiv   +5 more sources

What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems [PDF]

Nucl. Acids Res. (13 October 2014) 42 (18): 11321-11328, 2013
Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate selection in viral infection, cell cycle control, and development.
Berg, Johannes, Bhogale, Prasanna M., Sorg, Robin A., Veening, Jan-Willem   +3 more
arxiv   +5 more sources

Diffusion of transcription factors can drastically enhance the noise in gene expression [PDF]

arXiv, 2006
We study by simulation the effect of the diffusive motion of repressor molecules on the noise in mRNA and protein levels in the case of a repressed gene. We find that spatial fluctuations due to diffusion can drastically enhance the noise in gene expression.
Ander, Andrews, Andrews, Austin, Berg, Berg, Bialek, Bray, Bremer, Cai, Coppey, Delbruck, Detwiler, Eigen, Elf, Elowitz, Elowitz, Gerland, Gillespie, Gillespie, Golding, Golding, Gowers, Halford, Hornos, Hu, Jeroen S. van Zon, Kaern, Karmakar, Kepler, Kim, Klenin, Ko, Kushner, Lewis, Marco J. Morelli, McAdams, McClure, Metzler, Novick, Ozbudak, Paulsson, Paulsson, Peccoud, Pedraza, Pieter Rein ten Wolde, Pirone, Rao, Record, Revyakin, Riggs, Rigney, Rosenfeld, Shibata, Shoup, Simpson, Slutsky, Smoluchowski, Sorin Tǎnase-Nicola, Stanford, Swain, Tanase-Nicola, Thattai, Valitutti, van Kampen, van Kampen, van Zon, van Zon, Vilar, Warren, Warren, Yu   +71 more
arxiv   +7 more sources

Isolating intrinsic noise sources in a stochastic genetic switch [PDF]

, 2011
The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule that binds to the promotor of the other gene.
Gardiner C W, Jay M Newby, Ockendon J, Roma D M   +3 more
arxiv   +4 more sources

Repressors of anthocyanin biosynthesis [PDF]

New Phytologist, 2021
SummaryAnthocyanins play a variety of adaptive roles in both vegetative tissues and reproductive organs of plants. The broad functionality of these compounds requires sophisticated regulation of the anthocyanin biosynthesis pathway to allow proper localization, timing, and optimal intensity of pigment deposition.
Amy M. LaFountain, Yao‐Wu Yuan
openaire   +3 more sources

The MocR/GabR Ectoine and Hydroxyectoine Catabolism Regulator EnuR: Inducer and DNA Binding

Frontiers in Microbiology, 2021
The compatible solutes ectoine and 5-hydroxyectoine are widely synthesized by bacteria as osmostress protectants. These nitrogen-rich tetrahydropyrimidines can also be exploited as nutrients by microorganisms. Many ectoine/5-hydroxyectoine catabolic gene
Lucas Hermann, Lucas Hermann, Felix Dempwolff, Wieland Steinchen, Sven-Andreas Freibert, Sander H. J. Smits, Sander H. J. Smits, Andreas Seubert, Erhard Bremer, Erhard Bremer   +9 more
doaj   +1 more source

Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease [PDF]

International Neurourology Journal, 2022
Purpose Deregulation of SNCA encoding α-synuclein (α-SYN) has been associated with both the familial and sporadic forms of Parkinson disease (PD). Epigenetic regulation plays a crucial role in PD.
Subhrangshu Guhathakurta, Min Kyung Song, Sambuddha Basu, Goun Je, Ana Clara Cristovao, Yoon-Seong Kim   +5 more
doaj   +1 more source

Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000 Pseudomonas aeruginosa Genomes

Microorganisms, 2023
Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the pathogen Pseudomonas aeruginosa. Changes in their DNA binding regions, i.e., palindromic operators, can compromise pump depression and subsequently enhance ...
María Pérez-Vázquez, Carla López-Causapé, Andrés Corral-Lugo, Michael J. McConnell, Jesús Oteo-Iglesias, Antonio Oliver, Antonio J. Martín-Galiano   +6 more
doaj   +1 more source