Results 11 to 20 of about 491,654 (394)
An enhanced CRISPR repressor for targeted mammalian gene regulation [PDF]
Nature Methods, 2018 The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
Nan Cher Yeo +2 more
exaly +4 more sources
Genome-Wide Characterization of R2R3-MYB Transcription Factors in Pitaya Reveals a R2R3-MYB Repressor HuMYB1 Involved in Fruit Ripening through Regulation of Betalain Biosynthesis by Repressing Betalain Biosynthesis-Related Genes [PDF]
Cells, 2021 The MYB (myeloblastosis) superfamily constitutes one of the most abundant transcription factors (TFs) regulating various biological processes in plants. However, the molecular characteristics and functions of MYB TFs in pitaya remain unclear. To date, no
Fangfang Xie +8 more
doaj +2 more sources
Microorganisms, 2023 Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the pathogen Pseudomonas aeruginosa. Changes in their DNA binding regions, i.e., palindromic operators, can compromise pump depression and subsequently enhance ...
María Pérez-Vázquez +6 more
doaj +1 more source
Animals, 2023 PPARs are essential regulators of mammalian fatty acid and lipid metabolism. Although the effects of genetic variations, including single nucleotide polymorphisms (SNPs) in PPARs genes on the phenotype of domestic animals have been investigated, there is
Jia He +8 more
doaj +1 more source
NUPR1 is a critical repressor of ferroptosis
Nature Communications, 2021 Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive ...
Jiao Liu +7 more
semanticscholar +1 more source
The MocR/GabR Ectoine and Hydroxyectoine Catabolism Regulator EnuR: Inducer and DNA Binding
Frontiers in Microbiology, 2021 The compatible solutes ectoine and 5-hydroxyectoine are widely synthesized by bacteria as osmostress protectants. These nitrogen-rich tetrahydropyrimidines can also be exploited as nutrients by microorganisms. Many ectoine/5-hydroxyectoine catabolic gene
Lucas Hermann +9 more
doaj +1 more source
Repressors of anthocyanin biosynthesis [PDF]
New Phytologist, 2021 SummaryAnthocyanins play a variety of adaptive roles in both vegetative tissues and reproductive organs of plants. The broad functionality of these compounds requires sophisticated regulation of the anthocyanin biosynthesis pathway to allow proper localization, timing, and optimal intensity of pigment deposition.
Amy M. LaFountain, Yao‐Wu Yuan
openaire +2 more sources
Frontiers in Plant Science, 2021 Anthocyanins and proanthocyanidins (PAs) are important flavonoids in Chinese bayberry (Morella rubra), which functions in fruit color and exhibits multiple health promoting and disease-preventing effects.
Liyu Shi +6 more
doaj +1 more source
Conserved and Unique Functions of Blimp1 in Immune Cells
Frontiers in Immunology, 2022 B-lymphocyte-induced maturation protein-1 (Blimp1), is an evolutionarily conserved transcriptional regulator originally described as a repressor of gene transcription.
Samantha Nadeau +4 more
doaj +1 more source
Biomolecules, 2023 Saro_0803 is a transcriptional factor modulating the transcription of the stilbene-degrading enzyme gene nov1 in Novosphingobium aromaticivorans DSM 12444.
Zhen He +5 more
doaj +1 more source