Results 21 to 30 of about 496,166 (395)

What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems [PDF]

, 2014
Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate ...
Berg, Johannes, Bhogale, Prasanna M., Sorg, Robin A., Veening, Jan-Willem   +3 more
core   +2 more sources

The GbsR Family of Transcriptional Regulators: Functional Characterization of the OpuAR Repressor

Frontiers in Microbiology, 2018
Accumulation of compatible solutes is a common stress response of microorganisms challenged by high osmolarity; it can be achieved either through synthesis or import.
Stefanie Ronzheimer, Bianca Warmbold, Christian Arnhold, Erhard Bremer, Erhard Bremer   +4 more
doaj   +1 more source

Strong negative self regulation of Prokaryotic transcription factors increases the intrinsic noise of protein expression [PDF]

, 2008
Background Many prokaryotic transcription factors repress their own transcription. It is often asserted that such regulation enables a cell to homeostatically maintain protein abundance.
A Bar-Even, A Becskei, A de la Hoz, A Kierzek, C Cox, D Austin, Dafyd J Jenkins, Dov J Stekel, E Ozdubak, F Neidhardt, G Shinar, H El-Samad, I Keseler, J Paulsson, J Plumbridge, K Kostelidou, L Bingle, L Cai, M Elowitz, M Gibson, M Keeling, M Koern, M Samoilov, M Simpson, M Simpson, M Thattai, M Wall, N Rosenfeld, P Chivers, P Swain, Q Wang, R Rolfes, S Hooshangi, S Reichheld, T Kepler, Y Dublanche   +35 more
core   +4 more sources

A 314-bp SINE insertion in the ZNF2 promoter region may act as a repressor related to regulation of fat deposition in pigs

Journal of Integrative Agriculture, 2023
Retrotransposons, a type of DNA fragment that can mobilize itself on genome, can generate genetic variations and develop for molecular markers based on the insertion polymorphism.
Hao GU, Zhan-yu DU, Eduard MURANI, Enrico D'ALESSANDRO, Cai CHEN, Xiao-yan WANG, Jiu-de MAO, Klaus WIMMERS, Cheng-yi SONG   +8 more
doaj   +1 more source

Overexpression of PvPin1, a Bamboo Homolog of PIN1-Type Parvulin 1, Delays Flowering Time in Transgenic Arabidopsis and Rice

Frontiers in Plant Science, 2017
Because of the long and unpredictable flowering period in bamboo, the molecular mechanism of bamboo flowering is unclear. Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition ...
Zhigang Zheng, Xiaoming Yang, Yaping Fu, Longfei Zhu, Hantian Wei, Xinchun Lin   +5 more
doaj   +1 more source

Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]

, 2012
DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry, Bellomy, Bellomy, Brenowitz, Butler, Chen, Chen, Cloutier, Cloutier, Drew, Du, Echols, Edelman, Finzi, Frank, Garcia, Geggier, Han, Hirsh, Hogan, Hsieh, Jacobson, Krämer, Lewis, Lowary, Luger, Luijsterburg, Martin Lindén, Matthews, Mehta, Milstein, Morgan, Müller, Newman, Normanno, Oehler, Olson, Peters, Plischke, Ptashne, Rippe, Rob Phillips, Rutkauskas, Saiz, Schafer, Schleif, Segall, Shimada, Stephanie Johnson, Swigon, Tolhuis, Towles, Vanzi, Villa, Watson, Whitson, Whitson, Widom, Wong, Xu, Yin, Zhan, Zhang   +62 more
core   +4 more sources

Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs

Molecular Systems Biology, 2014
Most complex disease‐associated genetic variants are located in non‐coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis ...
Veronique Adoue, Alicia Schiavi, Nicholas Light, Jonas Carlsson Almlöf, Per Lundmark, Bing Ge, Tony Kwan, Maxime Caron, Lars Rönnblom, Chuan Wang, Shu‐Huang Chen, Alison H Goodall, Francois Cambien, Panos Deloukas, Willem H Ouwehand, Ann‐Christine Syvänen, Tomi Pastinen   +16 more
doaj   +1 more source

Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers?

Frontiers in Bioscience-Landmark, 2021
The epigenetic memory stored in the dynamic modifications, such as base modifications of cytosine (C) in DNA, including methylation/hydroxymethylation/demethylation, causes heritable phenotypes via regulating gene expression without alteration of DNA ...
Cuili Ma, Hwanwook Seong, Yumei Liu, Xiao Yu, Shuanliang Xu, Yujing Li   +5 more
doaj   +1 more source

An HIV feedback resistor: auto-regulatory circuit deactivator and noise buffer. [PDF]

, 2006
Animal viruses (e.g., lentiviruses and herpesviruses) use transcriptional positive feedback (i.e., transactivation) to regulate their gene expression.
Shenk, Thomas, Weinberger, Leor S
core   +4 more sources

Arabidopsis transcriptional repressor VAL1 triggers Polycomb silencing at FLC during vernalization

Science, 2016
The determinants that specify the genomic targets of Polycomb silencing complexes are still unclear. Polycomb silencing of Arabidopsis FLOWERING LOCUS C (FLC) accelerates flowering and involves a cold-dependent epigenetic switch.
Julia I Qüesta, Jie Song, N. Geraldo, Hailong An, C. Dean   +4 more
semanticscholar   +1 more source