Results 21 to 30 of about 382,695 (354)
What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems [PDF]
, 2014 Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate ...
Berg, Johannes +3 more
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Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs
Molecular Systems Biology, 2014 Most complex disease‐associated genetic variants are located in non‐coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis ...
Veronique Adoue +16 more
doaj +1 more source
Frontiers in Microbiology, 2019 AlkB monooxygenases in bacteria are responsible for the hydroxylation of medium- and long-chain n-alkanes. In this study, one CrgA protein of Pseudomonas aeruginosa SJTD-1, a member of LysR family, was proved to regulate AlkB2 monooxygenase and the ...
Nannan Ji +4 more
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Crystallization and preliminary crystallographic analysis of dUTPase from the helper phage Φ11 of Staphylococcus aureus [PDF]
, 2011 Staphylococcus aureus superantigen-carrying pathogenicity islands (SaPIs) have a determinant role in spreading virulence genes among bacterial populations that constitute a major health hazard.
Bendes, Ábris +5 more
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The GbsR Family of Transcriptional Regulators: Functional Characterization of the OpuAR Repressor
Frontiers in Microbiology, 2018 Accumulation of compatible solutes is a common stress response of microorganisms challenged by high osmolarity; it can be achieved either through synthesis or import.
Stefanie Ronzheimer +4 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 Retrotransposons, a type of DNA fragment that can mobilize itself on genome, can generate genetic variations and develop for molecular markers based on the insertion polymorphism.
Hao GU +8 more
doaj +1 more source
Accurate prediction of gene feedback circuit behavior from component properties [PDF]
, 2007 A basic assumption underlying synthetic biology is that analysis of genetic circuit elements, such as regulatory proteins and promoters, can be used to understand and predict the behavior of circuits containing those elements. To test this assumption, we
Alon U +6 more
core +2 more sources
Structure, 1996 Crystal and cocrystal structures of the LacI and PurR repressors reveal a novel use of hinge alpha helices which bind in the minor groove of the operator and mediate transmission of the allosteric signals that modulate DNA-binding activity.
openaire +3 more sources
Isolating intrinsic noise sources in a stochastic genetic switch [PDF]
, 2011 The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule that binds to
Newby, J. M.
core +2 more sources
Science, 2008 A factor implicated in autism spectrum disorders can both suppress and activate the expression of genes involved in neurodevelopment.
Michael E. Greenberg +2 more
openaire +2 more sources