Results 71 to 80 of about 6,797,208 (350)
Nature Communications, 2019 PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins ...
Mariya I. Goncheva +11 more
doaj +1 more source
The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. [PDF]
PLoS ONE, 2014 Loss of the chromatin remodeling ATPase CHD5 has been linked to the progression of neuroblastoma tumors, yet the underlying mechanisms behind the tumor suppressor role of CHD5 are unknown.
Jinhua Quan +4 more
doaj +1 more source
Salicylic acid receptors activate jasmonic acid signalling through a non-canonical pathway to promote effector-triggered immunity. [PDF]
, 2016 It is an apparent conundrum how plants evolved effector-triggered immunity (ETI), involving programmed cell death (PCD), as a major defence mechanism against biotrophic pathogens, because ETI-associated PCD could leave them vulnerable to necrotrophic ...
Dong, Xinnian +8 more
core +1 more source
A Splicing Repressor Domain in Polypyrimidine Tract-binding Protein [PDF]
Journal of Biological Chemistry, 2006 Polypyrimidine tract-binding protein (PTB) is an hnRNP with four RRM type domains. It plays roles as a repressive alternative splicing regulator of multilple target genes, as well as being involved in pre-mRNA 3' end processing, mRNA localization, stability, and internal ribosome entry site-mediated translation.
Fiona, Robinson, Christopher W J, Smith
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PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Epigenetic Control of Cytomegalovirus Latency and Reactivation
Viruses, 2013 Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate ...
Mary Hummel +5 more
doaj +1 more source
Regulated expression of a repressor protein: FadR activates iclR [PDF]
Journal of Bacteriology, 1996 The control of the glyoxylate bypass operon (aceBAK) of Escherichia coli is mediated by two regulatory proteins, IclMR and FadR. IclMR is a repressor protein which has previously been shown to bind to a site which overlaps the aceBAK promoter. FAR is a repressor/activator protein which participates in control of the genes of fatty acid metabolism.
L, Gui, A, Sunnarborg, D C, LaPorte
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases
Frontiers in Molecular Biosciences, 2023 Histone deacetylase 3 (HDAC3) and nuclear receptor co-repressor (NCoR1/2) are epigenetic regulators that play a key role in gene expression and metabolism.
Harikrishnareddy Paluvai +7 more
doaj +1 more source
Proteins of the ETS family with transcriptional repressor activity [PDF]
Oncogene, 2000 ETS proteins form one of the largest families of signal-dependent transcriptional regulators, mediating cellular proliferation, differentiation and tumorigenesis. Most of the known ETS proteins have been shown to activate transcription. However, four ETS proteins (YAN, ERF, NET and TEL) can act as transcriptional repressors.
G, Mavrothalassitis, J, Ghysdael
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