Results 51 to 60 of about 9,624 (189)

Resorufin Butyrate as a Soluble and Monomeric High-Throughput Substrate for a Triglyceride Lipase [PDF]

SLAS Discovery, 2012
Triglyceride lipases such as lipoprotein lipase, endothelial lipase, and hepatic lipase play key roles in controlling the levels of plasma lipoprotein. Accordingly, small-molecule modulation of these species could alter patient lipid profiles with corresponding health effects.
Vincent, Lam, Martin, Henault, Karine, Khougaz, Louis-Jacques, Fortin, Marc, Ouellet, Roman, Melnyk, Anthony, Partridge   +6 more
openaire   +2 more sources

Quantitative analysis of H2O2 transport through purified membrane proteins

MethodsX, 2020
Hydrogen peroxide (H2O2) is an important signal molecule produced in animal and plant cells. The balance of H2O2 between the intra- and extracellular space is regulated by integral membrane proteins, which thereby modulate signaling. Several methods have
Hao Wang, Stefan Schoebel, Florian Schmitz, Hansong Dong, Kristina Hedfalk   +4 more
doaj   +1 more source

A novel, low-cost microfluidic device with an integrated filter for rapid, ultrasensitive, and high-throughput bioburden detection

Scientific Reports, 2023
Rapid and accurate bioburden detection has become increasingly necessary for food, health, pharmaceutical and environmental applications. To detect bioburden accurately, and in a highly sensitive manner, we have fabricated a novel microfluidic device ...
Md. Sadique Hasan, Chad Sundberg, Michael Tolosa, Abhay Andar, Xudong Ge, Yordan Kostov, Govind Rao   +6 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

A SENSITIVE METHOD FOR SALIVA DETECTION IN FORENSICS USING SALIVARY AMYLASE COUPLED WITH AMPLEX RED OXIDATION

Journal of Experimental and Molecular Biology, 2021
A new sensitive method for saliva detection was developed, based on salivary amylase detection but with a final fluorescent product, which increases its sensitivity.
Sabina Bunescu, Bogdan Alexandru Stoica, Dragos Peptanariu, Liliana Foia   +3 more
doaj  

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source

Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization

eXPRESS Polymer Letters, 2012
The influence of the ionic character of a specific drug on its release rate from a hydrogel based on 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) is analyzed.
M. L. Gomez, R. J. J. Williams, H. A. Montejano, C. M. Previtali   +3 more
doaj   +1 more source

Biocompatible (Nano)Composites Based on Poly(ε‐Caprolactone)/Siloxene

Polymer Engineering &Science, EarlyView.
Bio‐inert and biocompatible pCLO/siloxene (nano)composites with enhanced mechanical properties. ABSTRACT The work focuses on the synthesis of the siloxene nanofiller and its subsequent use in the preparation of poly(ε‐caprolactone)/siloxene (nano)composites via in situ polymerization and melt blending.
Lucie Reinšteinová, Václava Benešová, Nikola Slepičková Kasálková, Jan Kočí, Jiří Brožek, Jonáš Uřičář   +5 more
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs

Sensors, 2009
In the present study, we characterized the kinetic parameters of 7-ethoxy-resorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation (MROD) in hepatic microsomes from entire and castrated male pigs.
Vladimir Zlabek, Galia Zamaratskaia
doaj   +1 more source