Results 1 to 10 of about 1,662,191 (275)

PSGL-1 is an evolutionarily conserved antiviral restriction factor [PDF]

mBio, 2023
The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to ...
Chao Jiang, Miao Mei, Ying Liu, Min Hou, Jun Jiao, Ya Tan, Xu Tan   +6 more
doaj   +2 more sources

The retroviral restriction factor TRIM5α [PDF]

Current Infectious Disease Reports, 2018
Retroviruses are obligate intracellular parasites that have coevolved with their hosts for millions of years. It is therefore not surprising that retroviruses take advantage of numerous host factors during their life cycle.
Luban, Jeremy, Sebastian, Sarah
core   +3 more sources

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication [PDF]

mBio
The SARS-CoV-2 pandemic and the emergence of novel variants underscore the need to understand host-virus interactions and identify host factors that restrict viral infection.
Fei Feng, Jiannan Chen, Rong Li, Yunkai Zhu, Yanlong Ma, Ziqiao Wang, Yuyan Wang, Zhichao Gao, Lulu Yang, Yin Yu, Yanfeng Liu, Yingjie Sun, Ying Liao, Xinxin Huang, Qisheng Zhang, Yongheng Huang, Lin Qiu, Jiayu Wu, Jingxian Zhao, Chao Liu, Qiang Ding, Youhua Xie, Zhenghong Yuan, Yue Hong, Ping Zhang, Jing Sun, Jincun Zhao, Rong Zhang   +27 more
doaj   +2 more sources

Mutagenic Analysis of the HIV Restriction Factor Shiftless [PDF]

Viruses, 2022
The interferon-induced host cell protein shiftless (SFL) was reported to inhibit human immunodeficiency virus (HIV) infection by blocking the –1 programmed ribosomal frameshifting (–1PRF) required for expression of the Gag-Pol polyprotein. However, it is
Niklas Jäger, Shreya Ahana Ayyub, Natalia Korniy, Frank Peske, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann   +6 more
doaj   +2 more sources

Discovery of a Novel Antiviral Effect of the Restriction Factor SPOC1 against Human Cytomegalovirus [PDF]

Viruses
The chromatin-remodeler SPOC1 (PHF13) is a transcriptional co-regulator and has been identified as a restriction factor against various viruses, including human cytomegalovirus (HCMV).
Anna K. Kuderna, Anna Reichel, Julia Tillmanns, Maja Class, Myriam Scherer, Thomas Stamminger   +5 more
doaj   +2 more sources

Cellular Restriction Factors of Feline Immunodeficiency Virus [PDF]

Viruses, 2011
Lentiviruses are known for their narrow cell- and species-tropisms, which are determined by cellular proteins whose absence or presence either support viral replication (dependency factors, cofactors) or inhibit viral replication (restriction factors ...
Carsten Münk, Jörg Zielonka
doaj   +3 more sources

Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity

Viruses, 2021
Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells.
William E. Diehl, Mehmet H. Guney, Teresa Vanzo, Pyae P. Kyawe, Judith M. White, Massimo Pizzato, Jeremy Luban   +6 more
doaj   +1 more source

Human Mannose Receptor 1 Attenuates HIV-1 Infectivity in a Virus Isolate-Specific Manner

Viruses, 2023
Human mannose receptor 1 (hMRC1) is a transmembrane glycoprotein that belongs to the C-type lectin family and is expressed on the surface of most tissue macrophages.
Hideki Saito, Sayaka Sukegawa, Sandra Kao, Klaus Strebel   +3 more
doaj   +1 more source

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels

mBio, 2023
Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells.
Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König   +7 more
doaj   +1 more source

Schlafens Can Put Viruses to Sleep

Viruses, 2022
The Schlafen gene family encodes for proteins involved in various biological tasks, including cell proliferation, differentiation, and T cell development. Schlafens were initially discovered in mice, and have been studied in the context of cancer biology,
Eui Tae Kim, Matthew D. Weitzman
doaj   +1 more source