Results 111 to 120 of about 5,014,214 (288)

ARRDC1 inhibits the replication of Semliki Forest virus by regulating the ubiquitination and degradation of viral nsP4

Journal of Virology
Alphavirus infection can result in a spectrum of clinical manifestations in the host, including fever, rash, arthritis, and even symptoms of encephalitis, thereby posing a severe threat to global public health security.
Qinyu Peng, Xiaoyi Yang, Cancan Chen, Junfang He, Yingan Liang, Xiaotong Luo, Changbai Huang, Wenbi Wu, Ping Zhang, Chao Liu   +9 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction

Journal of Virology
Several APOBEC3 enzymes restrict HIV-1 by deaminating cytosine to form uracil in single-stranded proviral (−)DNA. However, HIV-1 Vif counteracts their activity by inducing their proteasomal degradation.
Amit Gaba, Maria Yousefi, Shreoshri Bhattacharjee, Linda Chelico   +3 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. [PDF]

, 2010
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan.
Soppo, Charlotte Blanche Ekalle, Martin Klingenspor, Eugenio Scanziani, Hrabě de Angelis, M., Fabrizio Bianchi, Di Fiore, Pier Paolo, B. Pozzi, Offenhäuser Nina, Martin Hrabé de Angelis, Klingenspor Martin, B. Rathkolb, Horsch Marion, Horsch, Marion, Rathkolb, B., Nicole Ehrhardt, Wolf Eckhard, V. Gailus Durner, Tacchetti Carlo, Beckers, Johannes, Jan Rozman, Gailus-Durner, Valérie, Ralf Elvert, Hrabé de Angelis, Martin, Wolf, E., Ehrhardt, Nicole, Johannes Beckers, Elvert, Ralf, Tocchetti, Arianna, Pier Paolo Di Fiore, F. Bianchi, Elvert, R., A. Tocchetti, Horsch, M., Klingenspor, Martin, Bianchi, F., Moerth Corinna, Carlo Tacchetti, Ehrhardt Nicole, Pozzi, Benedetta, Scanziani Eugenio, Gagliani, M.C., Offenhäuser, N., Bianchi Fabrizio, Giorgio Scita, Birgit Rathkolb, M. C. Gagliani, Ehrhardt, N., Scita, G., Fuchs, Helmut, di Fiore, P.P., J. Beckers, Zani Fabio, Corinna Moerth, Eckhard Wolf, de Angelis Martin Hrabé, Mörth, C., Pozzi, B., Fuchs Helmut, M. Klingenspor, Beckers Johannes, M. Horsch, Tacchetti, C., Nina Offenhäuser, Rathkolb, Birgit, G. Scita, Tacchetti, Carlo, Bianchi, Fabrizio, Rozman, J., Rozman, Jan, Maria Cristina Gagliani, Charlotte Blanche Ekalle Soppo, Arianna Tocchetti, Ekalle Soppo Charlotte Blanche, Zani, F., N. Ehrhardt, Fuchs, H., J. Rozman, P.P. Di Fiore, Soppo, C.B.E., Valérie Gailus-Durner, Gailus-Durner, V., Gagliani, Maria Cristina, Moerth, Corinna, E. Scanziani, Scanziani, Eugenio, Helmut Fuchs, N. Offenhäuser, C. Tacchetti, Offenhäuser, Nina, Scita, Giorgio, Fabio Zani, C. Moerth, E. Wolf, Tocchetti, A., Elvert Ralf, Di Fiore Pier Paolo, M. Hrabé de Angelis, Tocchetti Arianna, Beckers, J., F. Zani, C. B. Soppo, Gagliani Maria Cristina, Scita Giorgio, Zani, Fabio, Scanziani, E., Klingenspor, M., Rathkolb Birgit, R. Elvert, Marion Horsch, Benedetta Pozzi, Pozzi Benedetta, Gailus-Durner Valérie, Wolf, Eckhard, Rozman Jan, H. Fuchs   +114 more
core   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5 [PDF]

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Takeuchi, Y., Schaller, T., Towers, G. J., Wood, A., Webb, B. L. J., Bartosch, B.   +5 more
core  

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Colon tumor promotion, is it a selection process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts [PDF]

, 1997
Promotion would suppose the selection of initiated cells. We tested the selection of aberrant crypt cells by cholic acid, a colon cancer promoter, and the effect of protectors, phytate and food restriction.
Peiffer, Ginette, Denis E. Corpet, Sylviane Taché, Taché, Sylviane, Ginette Peiffer, Corpet, Denis E.   +5 more
core   +1 more source