Results 11 to 20 of about 1,662,191 (275)

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Microbiology Spectrum, 2023
Mice are refractory to infection with human-tropic hepatitis C virus (HCV), although distantly related rodent hepaciviruses (RHV) circulate in wild rodents.
Yudi Zhang, Volker Kinast, Julie Sheldon, Nicola Frericks, Daniel Todt, Matthias Zimmer, Neva Caliskan, Richard J. P. Brown, Eike Steinmann, Thomas Pietschmann   +9 more
doaj   +1 more source

Antiretroviral restriction factors [PDF]

Current Opinion in Virology, 2011
Studies of retroviruses have been instrumental in revealing the existence of an array of antiviral proteins, or restriction factors, and the mechanisms by which they function. Some restriction factors appear to specifically inhibit retrovirus replication, while others have a broader antiviral action. Here, we briefly review current understanding of the
Theodora, Hatziioannou, Paul D, Bieniasz
openaire   +2 more sources

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

eLife, 2020
HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary conservation of Vpr suggests an important yet poorly understood role for macrophages in HIV pathogenesis.
Jay Lubow, Maria C Virgilio, Madeline Merlino, David R Collins, Michael Mashiba, Brian G Peterson, Zana Lukic, Mark M Painter, Francisco Gomez-Rivera, Valeri Terry, Gretchen Zimmerman, Kathleen L Collins   +11 more
doaj   +1 more source

Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I

Viruses, 2023
The seven human APOBEC3 enzymes (APOBEC3A through H, excluding E) are host restriction factors. Most of the APOBEC3 enzymes can restrict HIV-1 replication with different efficiencies. The HIV-1 Vif protein combats APOBEC3-mediated restriction by inducing
Maria Yousefi, Arun Kumar Annan Sudarsan, Amit Gaba, Linda Chelico   +3 more
doaj   +1 more source

Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway

Frontiers in Cellular and Infection Microbiology, 2020
Zika virus (ZIKV) is an emerging arthropod-borne virus and belongs to the Flaviviridae family. The infection of ZIKV has become the global health crisis because of its rapid spread and association with severe neurological disorders, including congenital ...
Xiaocao Ma, Xiaocao Ma, Xin Luo, Xin Luo, Shili Zhou, Shili Zhou, Yanxia Huang, Yanxia Huang, Cancan Chen, Changbai Huang, Changbai Huang, Li Shen, Li Shen, Ping Zhang, Ping Zhang, Chao Liu, Chao Liu   +16 more
doaj   +1 more source

Mouse APOBEC3 Restriction of Retroviruses

Viruses, 2020
Apolipoprotein B mRNA editing enzyme, catalytic peptide 3 (APOBEC3) proteins are critical host proteins that counteract and prevent the replication of retroviruses.
Karen Salas-Briceno, Wenming Zhao, Susan R. Ross   +2 more
doaj   +1 more source

Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses

Viruses, 2020
The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in humans and animals. The significant disease burden of these viruses is further exacerbated by the limited therapeutics that are
Rubaiyea Farrukee, Malika Ait-Goughoulte, Philippa M. Saunders, Sarah L. Londrigan, Patrick C. Reading   +4 more
doaj   +1 more source

Antiretroviral restriction factors in mice [PDF]

Virus Research, 2014
One of the most exciting areas in contemporary retrovirus research is the discovery of "restriction factors". These are cellular proteins that act after virus entry to inhibit infection by or replication of retroviruses (and other viruses and intracellular pathogens).
Smita, Nair, Alan, Rein
openaire   +2 more sources

A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. [PDF]

, 2013
C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice ...
Byerly, Mardi S, McCulloh, Patrick S, Seldin, Marcus M, Swanson, Roy, Wei, Zhikui, Wong, G William   +5 more
core   +6 more sources

Restriction and decay for flat hypersurfaces [PDF]

, 2002
In the first part we consider restriction theorems for hypersurfaces [Gamma] in Rn, with the affine curvature [fòrmula] introduced as a mitigating factor. Sjolin, [19], showed that there is a universal restriction theorem for all convex curves in R2.
Carbery, Anthony, Ziesler, Sarah
core   +2 more sources