Results 91 to 100 of about 501,662 (286)
Biology Open, 2013 Summary A significant fraction of mice deficient in either glial cell-derived neurotrophic factor (GDNF) or its co-receptors (Gfrα1, Ret), undergoes ureteric bud (UB) outgrowth leading to the formation of a rudimentary kidney.
James B. Tee +6 more
doaj +1 more source
Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease [PDF]
, 2010 Receptor tyrosine kinase (RET) single nucleotide polymorphisms (SNPs) are associated with the Hirschsprung's disease (HSCR). We investigated whether the amount of RET expressed in the ganglionic gut of human was dependent on the genotype of three ...
Chen, Y +9 more
core +1 more source
Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs
Clinical Pharmacology &Therapeutics, EarlyView.Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri +10 more
wiley +1 more source
Overview of management and therapeutic advances in medullary thyroid cancer
Endocrine OncologyMedullary thyroid carcinoma (MTC) is a rare cancer of the thyroid’s calcitonin-producing C cells. This review covers recent advances in MTC treatment, emphasizing surgical and systemic therapies.
Mark A Jara, Luciana Audi Castroneves
doaj +1 more source
mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum. [PDF]
, 2011 In the present study we aimed to verify if the enhancement of glial cell line-derived neurotrophic factor (GDNF) production in mouse striatum following treatment with LY379268 may also induce in the nigrostriatal system a time-related activation of RET ...
BELLUARDO, Natale +2 more
core +1 more source
Diagnostic Utility of Ki‐67 Index on Cell Block Material for Grading Medullary Thyroid Carcinoma
Diagnostic Cytopathology, EarlyView.ABSTRACT Introduction An international grading system for medullary thyroid carcinoma (IMTCGS) was established in 2022. High‐grade MTC is defined by the presence of one or more of the following features: mitotic index ≥ 5 per 2 mm2, Ki‐67 proliferative index ≥ 5%, or tumor necrosis.
Tieying Hou +3 more
wiley +1 more source
Does Neuroticism Disrupt the Psychological Benefits of Nostalgia? A Meta‐analytic Test
European Journal of Personality, EarlyView., 2020 Abstract Nostalgia, a sentimental longing or wistful affection for the past, confers self‐oriented, existential, and social benefits. We examined whether nostalgic engagement is less beneficial for individuals who are high in neuroticism (i.e. emotionally unstable and prone to negative affect).
Julius Frankenbach +4 more
wiley +1 more source
European Thyroid JournalObjective: At present, total thyroidectomy and central neck dissection are the surgical approaches recommended for the initial treatment of medullary thyroid cancer (MTC) independently of the size, number of tumor foci, age of patients, and other ...
Cappagli Virginia +10 more
doaj +1 more source
Synchronous primary papillary breast cancer, medullary thyroid carcinoma and neuroendocrine tumor in postmenopausal woman. [PDF]
, 2016 Multiple endocrine neoplasia are syndromes involving two or more endocrine tissues, often correlated to RET proto-oncogene mutations. We herein present the first reported case of a 57-years-old woman with three synchronous primary cancers of breast ...
DE IULIIS, Francesca +7 more
core
Drug Testing and Analysis, EarlyView.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source