Results 41 to 50 of about 501,662 (286)
THE NUCLEAR TECHNOLOGY IMPACT ON SUSTAINABLE DEVELOPMENT AND SECURITY [PDF]
Annals: Series on Military Sciences, 2013 On one hand, the nuclear technologies have a positive impact on sustainable development and security, but, on the other hand, they produce insecurity and bad prejudices on the sustainable development through the risks, threats and dangers which are ...
Eugen SITEANU, Benone ANDRONIC
doaj
Клиническая и экспериментальная тиреоидология, 2020 Autophagy is an important intracellular process that supports cell death and survival. Oncogenesis is associated with a change in the AKT/mTOR signaling pathway status.
Liudmila V. Spirina +3 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
ROMANIAS DEFENCE INFRASTRUCTURE DEVELOPMENT [PDF]
Annals: Series on Military Sciences, 2011 It is obvious that the infrastructure for defense represents a vital necessity for every nation in the context of the present day processes of European and international integration. Provision of current security, both at the European and national levels,
Eugen BĂDĂLAN, Eugen SITEANU
doaj
RET signaling pathway and RET inhibitors in human cancer
Frontiers in Oncology, 2022 Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty years ago as a novel transforming gene. Since its discovery and subsequent pathway characterization, RET alterations have been identified in numerous cancer types and are most prevalent in thyroid carcinomas and non-small cell lung cancer (NSCLC).
Angelina T. Regua +3 more
openaire +4 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Angewandte Chemie, EarlyView.A novel carbon dots material (BUL‐CDs) with an initial afterglow brightness (406 cd m−2) far exceeding that of other afterglow luminescent materials was developed. Furthermore, the BUL‐CDs exhibited time‐dependent afterglow colors, excitation‐dependent afterglow colors, and thermochromic afterglow in response to triplet variables.
Yupeng Liu +13 more
wiley +2 more sources
THE TOPICALITY OF RULER NEAGOE BASARAB'S MILITARY THINKING ON WAR AND ARMY [PDF]
Annals: Series on Military Sciences, 2010 Our great poet Vasile Alecsandri, making reference to the brilliant minds and epochal achievements of waivodes, rulers and past famous men of culture of the Romanian people, who served and protected in an exemplary manner our Country, Origin and ...
FIorian TUCĂ, Eugen SITEANU
doaj
Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer [PDF]
, 2017 Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas.
Andreas H. Scheel +44 more
core +1 more source
Advanced Engineering Materials, EarlyView.The study investigates novel semi‐finished products made of unidirectionally arranged hemp or pineapple leaf fiber‐reinforced composites produced from different matrices. The materials are analyzed in terms of their mechanical and interfacial properties and void content.
Nina Graupner +22 more
wiley +1 more source