Results 221 to 230 of about 238,606 (323)

NMNAT1 Activates Autophagy to Delay D‐Galactose‐Induced Aging in Cochlear Hair Cells

Aging Cell, Volume 25, Issue 2, February 2026.
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Yongjie Wei, Wenqing Yang, Han Wu, Mengdie Kong, Dachuan Fan, Yuhua Zhang, Nan Cheng, Jiawei Du, Lingna Guo, Yuyang Li, Ye Zhang, Qian Dai, Wei Cao, Jianming Yang, Qiaojun Fang   +14 more
wiley   +1 more source

Characterization of adeno-associated viral transduction of retinal ganglion cells in adult and old mice. [PDF]

Mol Ther Methods Clin Dev
Henderson DC, Chauhan BC.
europepmc   +1 more source

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.

Brain : a journal of neurology, 2014
V. Vigneswara, Nsikan Akpan, M. Berry, A. Logan, C. Troy, Zubair Ahmed   +5 more
semanticscholar   +1 more source

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

Aging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong, Xiaoyan Han, Siyi Qi, Duo Li, Jingyue Zhang, Linyu Zhang, Shujie Zhang, Qin Jiang, Biao Yan, Chen Zhao   +9 more
wiley   +1 more source

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway. [PDF]

Front Pharmacol
Yu H, Xu T, Feng Q, Wang Y, Zou J, Ma X.
europepmc   +1 more source

Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells.

Translational Vision Science & Technology, 2014
K. P. Gill, A. Hewitt, Kathryn C. Davidson, A. Pébay, R. C. Wong   +4 more
semanticscholar   +1 more source

Test–retest variability of the full‐field stimulus test in patients with retinitis pigmentosa: REPEAT Study Report No. 4

Acta Ophthalmologica, Volume 104, Issue 1, Page 89-97, February 2026.
Abstract Purpose To evaluate test–retest variability (TRV) of the full‐field stimulus test (FST) in patients with retinitis pigmentosa (RP) and poor best‐corrected visual acuity (BCVA; ≤20/50 Snellen; ≥0.40 logMAR), and to assess the reliability of FST as a clinical endpoint in future RP trials.
J. S. Karuntu, S. B. A. E. Tulp, C. J. F. Boon   +2 more
wiley   +1 more source

Neuroprotective effect of ripasudil on retinal ganglion cells via an antioxidative mechanism. [PDF]

Jpn J Ophthalmol
Yamagishi-Kimura R, Honjo M, Aihara M.
europepmc   +1 more source

Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

Proceedings of the National Academy of Sciences of the United States of America, 2014
Benjamin M. Gaub, Michael H. Berry, Amy Holt, Andreas Reiner, Michael A. Kienzler, N. Dolgova, S. Nikonov, G. Aguirre, W. Beltran, J. Flannery, E. Isacoff   +10 more
semanticscholar   +1 more source

Unilateral optic neuritis and thinning of retinal layers in the affected and unaffected eyes

Acta Ophthalmologica, Volume 104, Issue 1, Page e84-e94, February 2026.
Abstract Purpose Multiple sclerosis (MS)‐related optic neuritis (ON) causes thinning of inner retinal layers. It remains unclear whether unilateral MSON also affects the unaffected contralateral eye. The purpose of this study was to compare macular retinal layer thicknesses in MS eyes with unilateral optic neuritis (MSON), their unaffected ...
Sanna Leinonen, Hanna‐Mari Mäkelä, Chi Li, Leopold Schmetterer, Jacqueline Chua   +4 more
wiley   +1 more source