Results 181 to 190 of about 54,681 (257)

CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Ovarian cancer exhibits high molecular heterogeneity and metastatic potential, contributing to its status as a leading cause of gynecologic cancer mortality. Cell polarity is essential in tumorigenesis, yet the role of Crumbs family proteins (CRBs), key regulators of apical–basal polarity, in epithelial ovarian cancer (EOC) remains unclear. In
Chunlin Tao, Shaojing Li, Duohe Sun, Jun Zhou, Yuanping Chen, Rong Zhang, Xiaoge Ni   +6 more
wiley   +1 more source

A model for de novo pigmentation of amelanotic retinal pigment epithelial cells. [PDF]

Acta Ophthalmol
Gupta S, Lytvynchuk L, Ardan T, Studenovska H, Faura G, Eide L, Znaor L, Erceg S, Stieger K, Motlik J, Petrovski G.   +10 more
europepmc   +1 more source

MiR‐155‐5p promotes endothelial–mesenchymal transition and oxidative stress in diabetic retinopathy

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 599-607, April 2026.
ABSTRACT Aims MicroRNA (miRNA) has been confirmed to be related to gene expression regulation and disease progression. However, the role of miR‐155‐5p in diabetic retinopathy remains unclear. Materials and Methods The retinal microvascular endothelial cells (RMECs) were treated with high glucose, and then the changes of miR‐155‐5p, endothelial cell ...
Wenwen Dou, Changbo Fu, Lei Jin, Ting Li, Mingxing Li   +4 more
wiley   +1 more source

Effect of dopamine on TGF-β2 secretion by human retinal pigment epithelial cells and the underlying mechanism. [PDF]

PLoS One
Fan J, Zhang Q, Zheng L, Yang B, Jin H, Meng T, Ding Z.   +6 more
europepmc   +1 more source

Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 663-671, April 2026.
ABSTRACT Aims/Introduction Diabetic retinopathy (DR) is a prevalent chronic complication of type 2 diabetes mellitus (T2DM), contributing significantly to vision impairment. Circular RNAs (circRNAs) have emerged as key regulators in the pathogenesis of DR.
Wencheng An, Bingyan Wang, Fang Chen, Bo An, Shujing Zhou, Lin Jiang, Zhijun Cui, Xiaohong Ou, Wei Huang, Huixian Yan   +9 more
wiley   +1 more source

CRX is an intrinsic suppressor of epithelial‒mesenchymal transition in retinal pigment epithelial cells: a promising therapeutic avenue for subretinal fibrosis. [PDF]

Cell Death Dis
Li D, Ou Q, Gao F, Wang X, Zhu L, Zhou Y, Xu JY, Jin C, Wang J, Zhang J, Li J, Bi Y, Lu L, Xu GT, Tian H.   +14 more
europepmc   +1 more source

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Role of Endogenous Galectin-3 on Cell Biology of Immortalized Retinal Pigment Epithelial Cells In Vitro. [PDF]

Int J Mol Sci
Liesenhoff C, Hillenmayer M, Havertz C, Geerlof A, Hartmann D, Priglinger SG, Priglinger CS, Ohlmann A.   +7 more
europepmc   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

Structure-Activity Relationships of <i>N</i>-Acyl Dopamines in Inhibiting Myofibroblast Transdifferentiation of Retinal Pigment Epithelial Cells. [PDF]

Biomolecules
Zhao D, Motheramgari V, Freudenberger R, Shrader SH, Sloan LJ, Lung Z, Wang W, Tamiya S, Song ZH.   +8 more
europepmc   +1 more source