Results 1 to 10 of about 12,529 (75)

Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. [PDF]

PLoS ONE, 2012
Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma.
Justina McEvoy, Anatoly Ulyanov, Rachel Brennan, Gang Wu, Stanley Pounds, Jinghui Zhang, Michael A Dyer   +6 more
doaj   +1 more source

Update on pathology of retinoblastoma [PDF]

International Journal of Ophthalmology, 2018
Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor.
Lata Singh, Seema Kashyap
doaj   +1 more source

Bioinformatics analysis of key biomarkers for retinoblastoma

Journal of International Medical Research, 2021
Objective To identify key genes involved in occurrence and development of retinoblastoma. Methods The microarray dataset, GSE5222, was downloaded from the gene expression omnibus (GEO) database.
Xin-mei Zhao, Yuan-Bin Li, Peng Sun, Ya-di Pu, Meng-jie shan, Yuan-meng Zhang   +5 more
doaj   +1 more source

Comparison the Influence of Various Intensities of Aerobic Training on the Expression of RBL-1 and RB1 Genes in the Subcutaneous Adipose Tissue of Male Wistar Rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Background and Purpose: One of the most important methods to cope with obesity metabolic disorder is to do exercise activities that are both effective as a prevention and treatment.
Maryam Shavandi, Saeid Naghibi, Mohammad Shariatzadeh Joneydi, Maryam Vatandoust, Ali Zare   +4 more
doaj   +1 more source

Knockdown of NRMT enhances sensitivity of retinoblastoma cells to cisplatin through upregulation of the CENPA/Myc/Bcl2 axis

Cell Death Discovery, 2022
Chemotherapy resistance of tumor cells causes failure in anti-tumor therapies. Recently, N-terminal regulator of chromatin condensation 1 methyltransferase (NRMT) is abnormally expressed in different cancers.
Zhongrui Li, Lan Zhang, Dongrui Liu, Zhanghui Yang, Di Xuan, Yi Zhang   +5 more
doaj   +1 more source

A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal. [PDF]

PLoS ONE, 2011
Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease. Thus far only a few nuclear envelope proteins have been tested/found to affect cell cycle progression: to identify others, 39 novel
Nadia Korfali, Vlastimil Srsen, Martin Waterfall, Dzmitry G Batrakou, Vanja Pekovic, Christopher J Hutchison, Eric C Schirmer   +6 more
doaj   +1 more source

Regulation of p14^ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

BMC Cancer, 2012
Background Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found.
To Kwong-Him, Pajovic Sanja, Gallie Brenda L, Thériault Brigitte L   +3 more
doaj   +1 more source

Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases

Molecules, 2018
Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier studies on retinoblastoma have concentrated on the identification of key players in the disease and have not provided information on activated/inhibited ...
Lakshmi Dhevi Nagarajha Selvan, Ravikanth Danda, Anil K. Madugundu, Vinuth N. Puttamallesh, Gajanan J. Sathe, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, Thottethodi Subrahmanya Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda, Sailaja V. Elchuri   +12 more
doaj   +1 more source

The expression of retinoblastoma tumor suppressor protein in oral cancers and precancers: A clinicopathological study

Dental Research Journal, 2015
Background: The role of retinoblastoma (Rb) protein in cell cycle regulation prompted us to take up this study with the aim of assessing its role in the progression of oral cancer and to correlate with various clinicopathological parameters, including ...
Sunila Thomas, Anita Balan, Prabha Balaram   +2 more
doaj   +1 more source

Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line

Cancer Cell International, 2003
Background One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1). Studies employing many eukaryotic systems all point to a crucial role for PP1 activity in controlling cell cycle progression.
Klover Peter, Messing Edward M, Sowden Mark P, Reeder Jay E, Villa-Moruzzi Emma, Ludlow John W   +5 more
doaj   +1 more source