Results 11 to 20 of about 88,526 (282)

Knockdown of NRMT enhances sensitivity of retinoblastoma cells to cisplatin through upregulation of the CENPA/Myc/Bcl2 axis

Cell Death Discovery, 2022
Chemotherapy resistance of tumor cells causes failure in anti-tumor therapies. Recently, N-terminal regulator of chromatin condensation 1 methyltransferase (NRMT) is abnormally expressed in different cancers.
Zhongrui Li, Lan Zhang, Dongrui Liu, Zhanghui Yang, Di Xuan, Yi Zhang   +5 more
doaj   +1 more source

Comparison the Influence of Various Intensities of Aerobic Training on the Expression of RBL-1 and RB1 Genes in the Subcutaneous Adipose Tissue of Male Wistar Rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Background and Purpose: One of the most important methods to cope with obesity metabolic disorder is to do exercise activities that are both effective as a prevention and treatment.
Maryam Shavandi, Saeid Naghibi, Mohammad Shariatzadeh Joneydi, Maryam Vatandoust, Ali Zare   +4 more
doaj   +1 more source

Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. [PDF]

, 2017
A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification.
Bhatti, Tricia R., Eagle Jr., Ralph C., Ewens, Kathryn G., Ganguly, Arupa, Moran, Kimberly A., Richards-Yutz, Jennifer, Shields, Carol L.   +6 more
core   +2 more sources

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]

, 2016
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien, Colpaert, Robin, Creytens, David, Deforce, Dieter, Dimitrakopoulou, Dionysia, Haustraete, Jurgen, L, J, Lepez, Trees, Naert, Thomas, Steyaert, Wouter, Van Nieuwenhuysen, Tom, Vleminckx, Kris, Willaert, Andy   +12 more
core   +2 more sources

Retinoblastoma protein: Combating algal bloom [PDF]

Current Biology, 2001
The discovery of a homolog of the retinoblastoma protein (Rb) in a single-celled eukaryote--the alga Chlamydomonas--promises new and surprising insights into Rb's function in cell-cycle regulation.
Cross, Frederick R, Roberts, James M
openaire   +2 more sources

Regulation of p14^ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

BMC Cancer, 2012
Background Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found.
To Kwong-Him, Pajovic Sanja, Gallie Brenda L, Thériault Brigitte L   +3 more
doaj   +1 more source

Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases

Molecules, 2018
Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier studies on retinoblastoma have concentrated on the identification of key players in the disease and have not provided information on activated/inhibited ...
Lakshmi Dhevi Nagarajha Selvan, Ravikanth Danda, Anil K. Madugundu, Vinuth N. Puttamallesh, Gajanan J. Sathe, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, Thottethodi Subrahmanya Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda, Sailaja V. Elchuri   +12 more
doaj   +1 more source

Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations [PDF]

, 2015
Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina.
Alonso, Cristina, Ferrer, Marcela Maria, Giliberto, Florencia, Luce, Leonela Natalia, Ottaviani, Daniela, Parma, Diana Lidia, Szijan, Irena   +6 more
core   +1 more source

Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase

Stem Cell Research, 2018
The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors.
Jian Tu, Zijun Huo, Mo Liu, Donghui Wang, An Xu, Ruoji Zhou, Dandan Zhu, Julian Gingold, Jingnan Shen, Ruiying Zhao, Dung-Fang Lee   +10 more
doaj   +1 more source

A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling. [PDF]

PLoS Pathog, 2017
Nagendraprabhu P, Khatiwada S, Chaulagain S, Delhon G, Rock DL.   +4 more
europepmc   +3 more sources