Results 21 to 30 of about 12,529 (75)
Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]
Comptes Rendus Biologies, Elsevier, 2014, 337 (12), pp.661-678., 2014 Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology. This work proposes an algorithm for in silico target identification using Boolean network attractors.
arxiv +1 more source
PLoS ONE, 2023 The retinoblastoma protein (Rb) is encoded by the RB1 tumor suppressor gene. Inactivation of RB1 by inherited or somatic mutation occurs in retinoblastoma and various other types of tumors.
Mireia Palomar-Siles +3 more
doaj +1 more source
Current Assessment and Management of Retinoblastoma
Clinical Pediatric Hematology-Oncology, 2019 Retinoblastoma is the most common intraocular malignancy in childhood. Diagnosis is currently made by ophthalmologists under general anesthesia as it is the gold standard for intraocular assessment.
Hee Won Chueh
doaj +1 more source
Testing Monte Carlo absolute dosimetry formalisms for a small field `D'-shaped collimator used in retinoblastoma external beam radiotherapy [PDF]
Biomeical Physics & Engineering Express 2 (2016) 065008, 2018 Purpose: To investigate the validity of two Monte Carlo simulation absolute dosimetry approaches in the case of a small field dedicated `D'-shaped collimator used for the retinoblastoma treatment with external photon beam radiotherapy. Methods: The Monte Carlo code {\sc penelope} is used to simulate the linac, the dedicated collimator and a water ...
arxiv +1 more source
Insights from mouse models into human retinoblastoma
Cell Division, 2008 Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent tools for pre-clinical studies and for the ...
MacPherson David
doaj +1 more source
Predicting Pathogenicity Of nsSNPs Associated With Rb1 -- An In Silico Approach [PDF]
arXiv, 2023 Single nucleotide polymorphisms (SNPs) are variations at specific locations in DNA. Sequence responsible for marking genes associated with diseases or tracking inherited diseases within The family. These variations in the Rb1 gene can cause Retinoblastoma and cancer in the retina Of one eye or both, Osteosarcoma, Melanoma, Leukemias, Lungs, and Breast ...
arxiv
Monte Carlo study for designing a dedicated `D'-shaped collimator used in the external beam radiotherapy of retinoblastoma patients [PDF]
Medical Physics 41 (2014) 011714, 2018 Purpose: The purpose of the present article is to propose a modified version of the D-shaped collimator used at the Univ. Hosp. of Essen for retinoblastoma treatment that reduces even further the irradiation field with the scope to reduce the risk of radio-induced secondary malignancies.
arxiv +1 more source
Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]
, 2022 Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
arxiv +1 more source
Expression of multidrug resistance proteins in retinoblastoma [PDF]
International Journal of Ophthalmology, 2017 AIM: To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance. METHODS: Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or ...
Swati Shukla +8 more
doaj +1 more source
Early Prediction and Diagnosis of Retinoblastoma Using Deep Learning Techniques [PDF]
arXiv, 2021 Retinoblastoma is the most prominent childhood primary intraocular malignancy that impacts the vision of children and adults worldwide. In contrasting and comparing with adults it is uveal melanoma. It is an aggressive tumor that can fill and destroy the eye and the surrounding structures. Therefore early detection of retinoblastoma in childhood is the
arxiv