Results 31 to 40 of about 12,529 (75)

A study of the irradiation technique used for the external beam radiotherapy of retinoblastoma [PDF]

Physics in Medicine and Biology 57 (2012) 7741-7751, 2018
Purpose: Retinoblastoma (RB) is the most common eye tumor in childhood and can be treated external radiotherapy. The purpose of this work is to evaluate the adequacy of Monte Carlo simulations and the accuracy of a commercial treatment planning system by means of experimental measurements.
arxiv   +1 more source

A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions

Cancer Cell International, 2010
Background The interaction between viral oncoproteins such as Simian virus 40 TAg, adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB) occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a ...
Demone Jordan, Francis Sarah M, Henley Shauna A, Ainsworth Peter, Dick Frederick A   +4 more
doaj   +1 more source

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

Frontiers in Chemical Biology
IntroductionThe retinoblastoma protein (pRb) is a key regulator of the cell cycle that suppresses cell proliferation by binding to E2F transcription factors.
Carla Luciana Padilla Franzotti, Carla Luciana Padilla Franzotti, Nicolas Palopoli, Nicolas Palopoli, Juliana Palma, Juliana Palma, Gustavo Pierdominici-Sottile, Gustavo Pierdominici-Sottile   +7 more
doaj   +1 more source

Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility

Frontiers in Endocrinology, 2022
The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins exert their effects through binding to
Juho-Antti Mäkelä, Jorma Toppari, Jorma Toppari, Jorma Toppari   +3 more
doaj   +1 more source

Aspects of Diagnosis and Treatment of Retinoblastoma in Mongolia

Central Asian Journal of Medical Sciences, 2018
Objectives: To describe the clinical characteristics and the treatment outcome of retinoblastoma in Mongolian children. Methods: Data of all children diagnosed with retinoblastoma at the National Center for Maternal and Child Health of Mongolia from 1987
Tsengelmaa Chuluunbat, Bayalag Munkhuu, Uranchimeg Bazarsad, Altankhuu Molom, Baasankhuu Jamiyanjav   +4 more
doaj   +1 more source

Retinoblastoma. Part 1. Clinical presentations and diagnostic tools [PDF]

РМЖ "Клиническая офтальмология", 2020
Retinoblastoma. Part 1. Clinical presentations and diagnostic tools S.V. Ivanova1, S.A. Kuleva1, N.N. Sadovnikova2, M.I. Komissarov2, M.N. Chistyakova2, A.V. Khokhlova1, N.A. Shchegoleva3 1N.N.
S.V. Ivanova, S.A. Kuleva, N.N. Sadovnikova, M.I. Komissarov, M.N. Chistyakova, A.V. Khokhlova, N.A. Shchegoleva   +6 more
doaj  

In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]

ChemPhysChem 2020, 21, 377, 2019
We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
arxiv   +1 more source

Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction

Frontiers in Immunology, 2018
“High-risk” human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and disrupting cell cycle termination.
Paula Kuo, Siok Min Teoh, Zewen K. Tuong, Graham R. Leggatt, Stephen R. Mattarollo, Ian H. Frazer   +5 more
doaj   +1 more source

Bioactive Polymeric Nanoparticles of Moringa oleifera Induced Phyto-Photothermal Sensitization for the Enhanced Therapy of Retinoblastoma

Pharmaceutics, 2023
Treatment of retinoblastoma is limited due to its delayed detection and inaccesbility of drugs to reach the retina crossing the blood-retinal barrier. With the advancements in nanotechnology, photothermal therapy (PTT) employing plasmonic nanomaterials ...
Sushma Venkata Mudigunda, Deepak B. Pemmaraju, Sri Amruthaa Sankaranarayanan, Aravind Kumar Rengan   +3 more
doaj   +1 more source

A novel methodology on distributed representations of proteins using their interacting ligands [PDF]

Bioinformatics 2018, 2018
The effective representation of proteins is a crucial task that directly affects the performance of many bioinformatics problems. Related proteins usually bind to similar ligands. Chemical characteristics of ligands are known to capture the functional and mechanistic properties of proteins suggesting that a ligand based approach can be utilized in ...
arxiv   +1 more source