Results 41 to 50 of about 12,529 (75)

Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

Journal of Neuroinflammation, 2005
Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive.
Arendt Thomas, Veerhuis Robert, van Haastert Elise S, Hoozemans Jeroen JM, Scheper Wiep, Eikelenboom Piet, Rozemuller Annemieke JM   +6 more
doaj   +1 more source

Aberrant cytoplasmic accumulation of retinoblastoma protein in basal cells may lead to increased survival in malignant canine mammary tumours

Veterinární Medicína, 2014
The retinoblastoma susceptibility gene RB-1 is a tumour suppressor gene that encodes a protein (Rb) that regulates the transition from the G1 phase to the S phase of the cell cycle. Inactivation of the Rb gene has been shown in a variety of human tumours,
S. Gautam, N.K. Sood, K. Gupta
doaj   +1 more source

Correlation of serum concentration cyclin-dependent kinase 4 and cyclin-dependent kinase 6 with breast cancer in Babylon province

Medical Journal of Babylon, 2020
Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes.
Dalya Shakir Al-Owaidi, Moaed E Algazally, Alaa Sadeq Alawaad   +2 more
doaj   +1 more source

Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription

eLife, 2016
Newly born cells either continue to proliferate or exit the cell division cycle. This decision involves delaying expression of Cyclin E that promotes DNA replication.
Manzar Hossain, Bruce Stillman
doaj   +1 more source

Retinoblastoma protein is the likely common effector for distinct anti-aging pathways [PDF]

arXiv, 2007
The multiple worlds of genetically manipulated laboratory organisms such as transgenic mice or worms with certain gene mutations are somewhat reminiscent of parallel worlds in quantum mechanics. So are various models of aging tested in such organisms.
arxiv  

Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin. [PDF]

PLoS ONE, 2013
Verification that cell lines used for cancer research are derived from malignant cells in primary tumors is imperative to avoid invalidation of study results. Retinoblastoma is a childhood ocular tumor that develops from loss of functional retinoblastoma
Wesley S Bond, Patricia Y Akinfenwa, Laszlo Perlaky, Mary Y Hurwitz, Richard L Hurwitz, Patricia Chévez-Barrios   +5 more
doaj   +1 more source

Planet RB: a personal contribution to a proteomic map of human retinoblastoma protein [PDF]

arXiv, 2007
As I compress on the canvas of a few pages here major results of my research on the retinoblastoma tumor suppressor protein (RB) spreading over the past 15 years, an exciting picture emerges on this unique host molecule which surpasses in its complexity even that of the most capable viral proteins known to date.
arxiv  

Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase

Stem Cell Research, 2018
The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors.
Jian Tu, Zijun Huo, Mo Liu, Donghui Wang, An Xu, Ruoji Zhou, Dandan Zhu, Julian Gingold, Jingnan Shen, Ruiying Zhao, Dung-Fang Lee   +10 more
doaj  

The insulin superfamily of growth-promoting proteins [PDF]

arXiv, 2007
Recently, structural analysis of the human transferrin and growth hormone (GH) amino acid sequences has unravelled that they harbor a motif identical to a pattern found in viral oncoproteins known to bind the primarily nuclear tumor suppressor retinoblastoma protein (RB).
arxiv  

Restriction beyond the restriction point: mitogen requirement for G₂ passage

Cell Division, 2006
Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G1 restriction point, resulting in cell cycle arrest.
te Riele Hein, Foijer Floris
doaj   +1 more source