Results 21 to 30 of about 5,117,644 (334)

Effects of diet and strain on mouse serum and tissue retinoid concentrations. [PDF]

PLoS ONE, 2014
The relationship between dietary vitamin A and all-trans-retinoic acid levels in serum and tissues had not been quantified. We determined the impact of dietary vitamin A on retinoid levels in serum, liver, kidney, testis, and epididymal white adipose of ...
Kristin M Obrochta, Maureen A Kane, Joseph L Napoli   +2 more
doaj   +1 more source

Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases

Mediators of Inflammation, 2018
Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses.
L. Oliveira, F. M. Teixeira, M. Sato
semanticscholar   +1 more source

Retinoic acid and microRNA

, 2020
Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational ...
Yu-Jui Yvonne Wan, Lijun Wang, Atharva Rohatgi   +2 more
openaire   +3 more sources

Accumulation of hypoxia-inducible factor-1α protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid

Haematologica, 2008
Background The clinical activities of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia, have triggered extensive studies aimed at defining the mechanisms by which this compound induces ...
Jing Zhang, Li-Ping Song, Ying Huang, Qian Zhao, Ke-Wen Zhao, Guo-Qiang Chen   +5 more
doaj   +1 more source

TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models

Discover Oncology, 2023
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong, Xiaojun Liu, Weihua Ding, Lizhong Peng, Xuhui Zeng, Yayun Gu   +5 more
doaj   +1 more source

Generation of Retinaldehyde for Retinoic Acid Biosynthesis

Biomolecules, 2019
The concentration of all-trans-retinoic acid, the bioactive derivative of vitamin A, is critically important for the optimal performance of numerous physiological processes. Either too little or too much of retinoic acid in developing or adult tissues is
O. Belyaeva, Mark K. Adams, K. M. Popov, N. Kedishvili   +3 more
semanticscholar   +1 more source

Retinoic Acid and the Development of the Endoderm [PDF]

Journal of Developmental Biology, 2015
Retinoic acid (RA) is an important signaling molecule in the development of the endoderm and an important molecule in protocols used to generate endodermal cell types from stem cells. In this review, we describe the RA signaling pathway and its role in the patterning and specification of the extra embryonic endoderm and different endodermal organs. The
Kelly, Gregory M., Drysdale, Thomas A.
openaire   +4 more sources

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Journal of Experimental Medicine, 2007
To maintain immune homeostasis, the intestinal immune system has evolved redundant regulatory strategies. In this regard, the gut is home to a large number of regulatory T (T reg) cells, including the Foxp3+ T reg cell.
Cheng-Ming Sun, J. Hall, J. Hall, R. Blank, N. Bouladoux, M. Oukka, J. Mora, Y. Belkaid   +7 more
semanticscholar   +1 more source

Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.

PLoS ONE, 2011
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu   +8 more
doaj   +1 more source

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.

New England Journal of Medicine, 2013
BACKGROUND All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%.
F. Lo‐Coco, G. Avvisati, M. Vignetti, C. Thiede, S. Orlando, S. Iacobelli, F. Ferrara, P. Fazi, L. Cicconi, E. di Bona, G. Specchia, S. Sica, M. Divona, A. Levis, W. Fiedler, E. Cerqui, M. Breccia, G. Fioritoni, H. Salih, M. Cazzola, L. Melillo, A. Carella, C. Brandts, E. Morra, M. von Lilienfeld-Toal, B. Hertenstein, M. Wattad, M. Lübbert, M. Hänel, N. Schmitz, H. Link, M. Kropp, A. Rambaldi, G. La Nasa, M. Luppi, F. Ciceri, O. Finizio, A. Venditti, F. Fabbiano, K. Döhner, M. Sauer, A. Ganser, S. Amadori, F. Mandelli, H. Döhner, G. Ehninger, R. Schlenk, U. Platzbecker   +47 more
semanticscholar   +1 more source