Results 21 to 30 of about 223,790 (352)

TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models

Discover Oncology, 2023
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong, Xiaojun Liu, Weihua Ding, Lizhong Peng, Xuhui Zeng, Yayun Gu   +5 more
doaj   +1 more source

Accumulation of hypoxia-inducible factor-1α protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid

Haematologica, 2008
Background The clinical activities of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia, have triggered extensive studies aimed at defining the mechanisms by which this compound induces ...
Jing Zhang, Li-Ping Song, Ying Huang, Qian Zhao, Ke-Wen Zhao, Guo-Qiang Chen   +5 more
doaj   +1 more source

Effects Of Retinoic Acid On Prostaglandin Biosynthesis In Guinea-Pig Skin [PDF]

, 1975
Topical application of retinoic acid on guinea-pig skin resulted within 70 hours in erythema with a concomitant elevation of endogenous prostaglandin E2 (PGE2) in the treated areas of the skin.
Ziboh, Vincent A., Price, Buddy, Fulton, James   +2 more
core   +1 more source

HLXB9 gene expression, and nuclear location during in vitro neuronal differentiation in the SK-N-BE neuroblastoma cell line [PDF]

, 2014
Copyright @ 2014 Leotta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Brundo, MV, Federico, C, Leotta, CG, Saccone, S, Tosi, S   +4 more
core   +1 more source

Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.

PLoS ONE, 2011
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu   +8 more
doaj   +1 more source

13-cis-retinoic acid is an endogenous compound in human serum.

Journal of Lipid Research, 1990
The occurrence of 13-cis-retinoic acid as an endogenous component in human serum has been confirmed by cochromatography with standards in both normal-phase and reverse-phase high-performance liquid chromatographic (HPLC) system, by the lambda max of its ...
GW Tang, RM Russell
doaj   +1 more source

Reference loci for RT-qPCR analysis of differentiating human embryonic stem cells [PDF]

, 2013
Background: Selecting stably expressed reference genes is essential for proper reverse transcription quantitative polymerase chain reaction gene expression analysis. However, this choice is not always straightforward. In the case of differentiating human
De Sutter, Petra, Deforce, Dieter, Heindryckx, Björn, O'Leary, Thomas, Van Neste, Christophe, Vandesompele, Jo, Vossaert, Liesbeth   +6 more
core   +2 more sources

Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6. [PDF]

, 2015
Vitamin A has biological functions as diverse as sensing light for vision, regulating stem cell differentiation, maintaining epithelial integrity, promoting immune competency, regulating learning and memory, and acting as a key developmental morphogen ...
Kassai, Miki, Kawaguchi, Riki, Sun, Hui, Ter-Stepanian, Mariam, Zhong, Ming   +4 more
core   +2 more sources

Detection and mode of action of retinoids on ovarian development in the mud crab, Scylla serrata

International Journal of Aquatic Biology, 2019
In the current study, the retinoic acid isomers such as 9-cis retinoic acid and all-trans retinoic acid were detected in the mature ovaries of mud crabs, Scylla serrata using HPLC analysis.
Kaduru Venkaiah, Daveedu Thathapudi, Sri Bhashyam Sainath   +2 more
doaj   +1 more source

Potential Therapeutic Effect of All-Trans Retinoic Acid on Atherosclerosis

Biomolecules, 2022
Atherosclerosis is a major risk factor for myocardial infarction and ischemic stroke, which are the leading cause of death worldwide. All-trans retinoic acid (ATRA) is a natural derivative of essential vitamin A.
Qile Deng, Jixiang Chen
doaj   +1 more source