Results 131 to 140 of about 146,563 (345)

The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited

Nature Communications, 2017
The molecular switch between how tumour necrosis factor (TNF) controls inflammation versus cell death is less well defined. Here, the authors show that the nuclear receptor retinoic acid receptor gamma is released from the nucleus to disrupt TNF ...
Qing Xu, Siriporn Jitkaew, Swati Choksi, Chamila Kadigamuwa, Jianhui Qu, Moran Choe, Jonathan Jang, Chengyu Liu, Zheng-gang Liu   +8 more
doaj   +1 more source

All-Trans Retinoic Acid and Sodium Butyrate Enhance Natriuretic Peptide Receptor A Gene Transcription: Role of Histone Modification [PDF]

, 2014
Prerna Kumar, Ramu Periyasamy, Subhankar Das, Smitha Neerukonda, Indra Mani, Kailash N. Pandey   +5 more
openalex   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Transcriptional Regulation by Transforming Growth Factor β of the Expression of Retinoic Acid and Retinoid X Receptor Genes in Osteoblastic Cells Is Mediated through AP-1 [PDF]

, 1996
Yun Chen, Akira Takeshita, Ken Ozaki, Shigeo Kitano, Shigemasa Hanazawa   +4 more
openalex   +1 more source

Synthesis of Unsymmetric Bis(heteroaryl) Selenides by Rhodium‐Catalyzed Exchange Reaction of Heteroaryl Fluorides and Ethers Using Se‐Heteroaryl Carboselenoates

European Journal of Organic Chemistry, EarlyView.
Various unsymmetric bis(heteroaryl) selenides are synthesized by the rhodium‐catalyzed exchange reaction of heteroaryl fluorides and ethers with Se‐heteroaryl 1‐adamatanecarboselenoates. The synthetic method is applicable to a broad range of five‐ and six‐membered heteroaryl derivatives and provides compounds containing multiple heteroatoms.
Masana Yazaki, Wei Han, Ren Suzuki, Mieko Arisawa   +3 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats

Frontiers in Neuroscience
Increasing evidence suggests that all-trans retinoic acid (ATRA) contributes to the pathogenesis of depression. Although numerous studies have emphasized the role of hippocampal glutamatergic transmission and dendritic spine abnormalities in ATRA-induced
Yuan-Zhong Kai, Chun Xia, Qing-Hong Shan, Zheng-Quan Tang   +3 more
doaj   +1 more source

One‐Stone‐Two‐Birds Carrier‐Free Nano‐Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment

Exploration, EarlyView.
ABSTRACT Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness characteristics in non‐stem cancer cells. Herein, we propose a cancer cells/CSCs double‐killing modality
Tongyao Zhao, Yao Chen, Haimeng Yuan, Shuqian Yang, Hongyuan Zhang, Yuequan Wang, Shenwu Zhang, Qin Chen, Jin Sun, Zhonggui He, Cong Luo   +10 more
wiley   +1 more source

Case report: Successful therapy with azacitidine for acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia

Frontiers in Oncology
We report a case of acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) rearrangement, exhibiting clinical, morphological, and immunophenotypic features similar to classic acute promyelocytic leukemia (APL).
Zhichen Wei, Linlin Shao, Shuqian Xu, Xiaolin Zhang, Lin Wang, Ping Qin, Qiang Song, Ming Hou, Ming Hou, Yan Shi   +9 more
doaj   +1 more source