Results 251 to 260 of about 146,563 (345)

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Ganoderic Acid A alleviates ulcerative colitis by inhibiting the interleukin17 signaling pathway via targeting retinoic acid-related orphan receptor alpha

Yifei Ye, Yinni Chen, Yinni Chen, Yiyang Cao, T Liu, Yu Hu, Xi Chen, Xiangnuo Han, Shu Yang, Shun Li, Yuanli Chen, Yuanli Chen, Zhihao Xu   +12 more
openalex   +1 more source

The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1

, 2004
Caroline Chauvet, Brigitte Bois-Joyeux, Edurne Berra, Jacques Pouysségur, Jean-Louis Danan   +4 more
openalex   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Adipocyte retinoic acid receptor α prevents obesity and steatohepatitis by regulating energy expenditure and lipogenesis. [PDF]

Obesity (Silver Spring)
Cassim Bawa FN, Hu S, Gopoju R, Shiyab A, Mongan K, Xu Y, Pan X, Clark A, Wang H, Zhang Y.   +9 more
europepmc   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair. [PDF]

Front Mol Neurosci
Goncalves MB, Wu Y, Clarke E, Grist J, Moehlin J, Mendoza-Parra MA, Hobbs C, Kalindjian B, Fok H, Mander AP, Hassanin H, Bendel D, Täubel J, Mant T, Carlstedt T, Jack J, Corcoran JPT.   +16 more
europepmc   +1 more source

Selective Promotion of Retinal Organoid Attachment and Differentiation by Amine‐ and Hydroxyl‐Modified Surfaces

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Engineered biomaterial interfaces critically control retinal organoid development. This study examines how surface modifications (amine, hydroxyl, phenyl, and methyl groups) dictate organoid response. Hydrophilic surfaces markedly increase migration and foster retinal ganglion cell differentiation.
Luis Marcos, Charlie Hall, Eric J. Hill, Samantha L. Wilson, Paul Roach   +4 more
wiley   +1 more source

Retinoic acid receptor (RAR) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source