Results 261 to 270 of about 3,704,275 (297)
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1992
Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Retinoids, Retinoic Acid Receptors, and Cancer
Annual Review of Pathology: Mechanisms of Disease, 2011Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but not all of the effects of retinoids. Retinoid signaling is often compromised early in carcinogenesis, which suggests that a reduction in retinoid signaling may ...
Xiao-Han, Tang, Lorraine J, Gudas
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Identification of a receptor for the morphogen retinoic acid
Nature, 1987Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
V, Giguere +3 more
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Developmental roles of the retinoic acid receptors
The Journal of Steroid Biochemistry and Molecular Biology, 1995Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced ...
Lohnes, David +8 more
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Nouvelle revue francaise d'hematologie, 1990
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
H, de Thé, P, Tiollais, A, Dejean
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Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
H, de Thé, P, Tiollais, A, Dejean
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Mechanisms of transactivation by retinoic acid receptors
BioEssays, 1993AbstractRetinoids play an important role in development and differentiation(1,2). Their effect is mediated through nuclear receptors, RAR (α, β and γ) and RXR (α, β and γ),Abbreviations. RAR: retinoic acid receptor; RXR: retinoid X receptor; T3:thyroid hormone receptor; VD3R: vitamin D3 receptor; PPAR: peroxisome proliferator activated receptor; EcR ...
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Retinoic acid receptors, hematopoiesis and leukemogenesis
Current Opinion in Hematology, 2008All-trans retinoic acid therapy of acute promyelocytic leukemia represents the most successful example of differentiation-induction therapy in clinical oncology. However, acute promyelocytic leukemia represents only a small minority (10-15%) of the myeloid leukemias.
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