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Chronicle of a discovery: the retinoic acid receptor
Journal of Molecular Endocrinology, 2022The landmark 1987 discovery of the retinoic acid receptor (RAR) came as a surprise, uncovering a genomic kinship between the fields of vitamin A biology and steroid receptors. This stunning breakthrough triggered a cascade of studies to deconstruct the roles played by the RAR and its natural and synthetic ligands in embryonic development, skin, growth,
Vincent Giguère, Ronald M Evans
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Retinoic acid and its receptors
The American Journal of Surgery, 1993Retinoic acid (RA)--the active metabolite of vitamin A--and its analogues have pleiotropic effects on growth, differentiation, proliferation, and development. RA, and its analogues, determine embryonic pattern formation and inhibit tumor growth; however, they are also teratogens.
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Transcriptional Activities of Retinoic Acid Receptors
2005Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend however beyond embryonic development, and tissue homeostasis, lipid metabolism, cellular differentiation and proliferation are in part controlled through the retinoid ...
Lefebvre, P. +5 more
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Altered retinoic acid receptors
The FASEB Journal, 1996Structurally and functionally altered retinoic acid receptors have been associated with rare human neoplasms: acute promyelocytic leukemia and hepatocellular carcinoma. Whereas the ret‐ inoic acid receptor β (RARβ) rearrangement in hepatocellular carcinoma is unique, in acute promyelocytic leukemia (APL), RARα fusion to the ...
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Retinoic acid receptors at 35 years
Journal of Molecular Endocrinology, 2022For almost a century, vitamin A has been known as a nutrient critical for normal development, differentiation, and homeostasis; accordingly, there has been much interest in understanding its mechanism of action. This review is about the discovery of specific receptors for the vitamin A derivative, retinoic acid (RA), which launched
Petkovich, Martin, Chambon, Pierre
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1995
Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System
Annual Review of Immunology, 2016Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell involved in protective or regulatory adaptive or innate immunity.
Alexandre, Larange, Hilde, Cheroutre
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2015
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
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Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
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2010
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
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Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
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Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors
The International Journal of Developmental Biology, 1995An excess of retinoic acid (RA) in the mouse embryo in utero produces hypochondrogenesis and severe limb bone deformities. Since one of the RA receptors--RAR-beta 2, is specifically induced in the limb bud cells upon treatment of embryos with teratogenic doses of RA, we investigated if this receptor played a role in teratogenesis by regulating the ...
H, Jiang +6 more
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