Retinoid X Receptor Activation Prevents Diabetic Retinopathy in Murine Models [PDF]
Cells, 2023 Previously, the RXR agonist UAB126 demonstrated therapeutic potential to treat obese mice by controlling blood glucose levels (BGL) and altering the expression of genes associated with lipid metabolism and inflammatory response.
Iuliia Dorofeeva +7 more
doaj +4 more sources
Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential [PDF]
Frontiers in PharmacologyNuclear receptors (NRs) are key regulators of multiple physiological functions and pathological changes in the liver in response to a variety of extracellular signaling changes.
Renjie Xu +3 more
doaj +3 more sources
Of Retinoids and Organotins: The Evolution of the Retinoid X Receptor in Metazoa [PDF]
Biomolecules, 2020 Nuclear receptors (NRs) are transcription factors accomplishing a multiplicity of functions, essential for organismal homeostasis. Among their numerous members, the retinoid X receptor (RXR) is a central player of the endocrine system, with a singular ...
Elza Fonseca +5 more
doaj +4 more sources
Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA [PDF]
Computational and Structural Biotechnology Journal, 2023 Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. FXR
Longying Jiang +8 more
doaj +2 more sources
Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin. [PDF]
PLoS ONE, 2013 Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases.
Janine Gericke +7 more
doaj +6 more sources
Dietary Phenolic Compounds Exert Some of Their Health-Promoting Bioactivities by Targeting Liver X Receptor (LXR) and Retinoid X Receptor (RXR) [PDF]
Foods, 2023 Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in ...
J. Abraham Domínguez-Avila
doaj +2 more sources
Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent [PDF]
Annals of Clinical and Translational Neurology, 2022 Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened the visual evoked
Christopher E. McMurran +7 more
doaj +2 more sources
Targeting the Retinoid X Receptor Pathway Prevents and Ameliorates Murine Chronic Graft-Versus-Host Disease [PDF]
Frontiers in Immunology, 2022 Most allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients receive peripheral blood stem cell grafts resulting in a 30%–70% incidence of chronic graft-versus-host disease (cGVHD), a major cause of mortality and morbidity in long-term ...
Govindarajan Thangavelu +10 more
doaj +2 more sources
Journal of Ginseng Research, 2019 Background: Ginseng has a wide range of beneficial effects on health, such as the mitigation of minor and major inflammatory diseases, cancer, and cardiovascular diseases. There are abundant data regarding the health-enhancing properties of whole ginseng
Evelyn Saba +7 more
doaj +2 more sources
Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-Synucleinopathy [PDF]
CellsThis study investigated the therapeutic potential of the nuclear retinoid X receptor (RXR) in mitigating the progression of alpha-synucleinopathies (αSNPs), particularly in Parkinson’s disease (PD).
Assylbek Zhylkibayev +8 more
doaj +2 more sources