Of Retinoids and Organotins: The Evolution of the Retinoid X Receptor in Metazoa. [PDF]
Biomolecules, 2020 Nuclear receptors (NRs) are transcription factors accomplishing a multiplicity of functions, essential for organismal homeostasis. Among their numerous members, the retinoid X receptor (RXR) is a central player of the endocrine system, with a singular ...
Fonseca E +5 more
europepmc +7 more sources
Retinoid X Receptor Antagonists. [PDF]
Int J Mol Sci, 2018 Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved ...
Watanabe M, Kakuta H.
europepmc +6 more sources
Retinoid X Receptor Activation Prevents Diabetic Retinopathy in Murine Models. [PDF]
Cells, 2023 Previously, the RXR agonist UAB126 demonstrated therapeutic potential to treat obese mice by controlling blood glucose levels (BGL) and altering the expression of genes associated with lipid metabolism and inflammatory response.
Dorofeeva I +7 more
europepmc +2 more sources
Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement. [PDF]
Mol Neurobiol, 2022 Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with particularly high evolutionary conservation of ligand binding domain.
Sharma S +10 more
europepmc +2 more sources
Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA. [PDF]
Comput Struct Biotechnol J, 2023 Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. FXR
Jiang L +8 more
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Dietary Phenolic Compounds Exert Some of Their Health-Promoting Bioactivities by Targeting Liver X Receptor (LXR) and Retinoid X Receptor (RXR). [PDF]
Foods, 2023 Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in ...
Domínguez-Avila JA.
europepmc +2 more sources
Targeting the Retinoid X Receptor Pathway Prevents and Ameliorates Murine Chronic Graft-Versus-Host Disease. [PDF]
Front Immunol, 2022 Most allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients receive peripheral blood stem cell grafts resulting in a 30%–70% incidence of chronic graft-versus-host disease (cGVHD), a major cause of mortality and morbidity in long-term ...
Thangavelu G +10 more
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Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor [PDF]
Journal of Biological Chemistry, 2000 Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding cassette transporter ABC1.
Philippe Costet +3 more
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Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential. [PDF]
Front PharmacolNuclear receptors (NRs) are key regulators of multiple physiological functions and pathological changes in the liver in response to a variety of extracellular signaling changes.
Xu R, Zhang L, Pan H, Zhang Y.
europepmc +2 more sources
Remyelination in humans due to a retinoid-X receptor agonist is age-dependent. [PDF]
Ann Clin Transl Neurol, 2022 Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened the visual evoked
McMurran CE +7 more
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