The Roles and Clinical Significance of Major Hepatic‐Derived Metabolites in Hepatocellular Carcinoma
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Hepatocellular carcinoma (HCC) is increasingly recognized as a metabolically orchestrated malignancy, in which hepatic‐derived metabolites function not only as byproducts of liver physiology but also as active modulators of tumor biology.
Rui Sun +5 more
wiley +1 more source
Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells. [PDF]
, 1994 Saverio Minucci +6 more
openalex +1 more source
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth +5 more
wiley +1 more source
Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. [PDF]
, 1992 Thomas J. Berrodin +4 more
openalex +1 more source
Activation of Retinoid X Receptor increases dopamine cell survival in models for Parkinson's disease
BMC Neuroscience, 2009 Background Parkinson's disease (PD) is caused by degeneration of dopamine (DA) neurons in the ventral midbrain (vMB) and results in severely disturbed regulation of movement. The disease inflicts considerable suffering for the affected and their families.
Bergsland Maria +2 more
doaj +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste +4 more
wiley +1 more source
Retinoid X Receptor agonists as selective modulators of the immune system for the treatment of cancer. [PDF]
Pharmacol Ther, 2023 Leal AS, Hung PY, Chowdhury AS, Liby KT.
europepmc +1 more source
Pediatric Dermatology, EarlyView.ABSTRACT Pityriasis rubra pilaris (PRP) is a rare, chronic papulosquamous disorder with limited treatment options in pediatric patients. We report the case of a 9‐year‐old boy with juvenile PRP (type III), who achieved complete disease remission after treatment with secukinumab, an IL‐17A inhibitor, following initial therapeutic resistance to topical ...
Zeno Fratton +2 more
wiley +1 more source
Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor. [PDF]
, 1994 Manoj K. Bhat +2 more
openalex +1 more source
Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. [PDF]
, 2017 PurposeThe RPE cell line ARPE-19 provides a dependable and widely used alternative to native RPE. However, replication of the native RPE phenotype becomes more difficult because these cells lose their specialized phenotype after multiple passages ...
Duncan, Todd +8 more
core +2 more sources