Results 41 to 50 of about 155,897 (329)

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

Molecular and Cellular Biology, 2001
Tomohiro Yoshikawa, Hitoshi Shimano, Michiyo Amemiya-Kudo, Naoya Yahagi, Alyssa H. Hasty, Takashi Matsuzaka, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Jun-ichi Osuga, Kenji Harada, Takanari Gotoda, Satoshi Kimura, Shun Ishibashi, Nobuhiro Yamada   +15 more
openalex   +2 more sources

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]

, 2017
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo, Ana Cañete, Arguello, Cardoso, Dary, De Luca, Elena Cano, Gebremedhin, Gerster, Grande, Guo, Haussler, Kuwata, Lo-Coco, McLaren, Nervi, North, Ottersbach, O’Donnell, Ramón Muñoz-Chápuli, Rita Carmona, Ross, Testa, West   +23 more
core   +4 more sources

The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity [PDF]

Neurotoxicity Research, 2015
Dichlorodiphenyldichloroethylene (DDE) is a primary environmental and metabolic degradation product of the pesticide dichlorodiphenyltrichloroethane (DDT). It is one of the most toxic compounds belonging to organochlorines. DDE has never been commercially produced; however, the parent pesticide DDT is still used in some developing countries for disease-
Wnuk A., Rzemieniec J., Litwa E., Lason W., Krzeptowski W., Wojtowicz A. K., Kajta M.   +6 more
openaire   +5 more sources

Auto-silencing by the retinoid X receptor

Journal of Molecular Biology, 1998
Gene transcription is often regulated by small ligands, enabling cells to respond to external and metabolic stimuli. Of particular interest are the mechanisms by which hydrophobic hormones modulate the transcriptional activities of proteins of the nuclear receptor superfamily.
Diane Dong, Sander Kersten, Wen yi Lee, Peter R. Reczek, Noa Noy   +4 more
openaire   +3 more sources

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

Nature Communications, 2017
The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insights ...
Jie Zheng, Mi Ra Chang, Ryan E. Stites, Yong Wang, John B. Bruning, Bruce D. Pascal, Scott J. Novick, Ruben D. Garcia-Ordonez, Keith R. Stayrook, Michael J. Chalmers, Jeffrey A. Dodge, Patrick R. Griffin   +11 more
doaj   +1 more source

Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism

Biomedicines, 2022
No therapy exists for non-alcoholic fatty liver disease (NAFLD). However, glucagon-like peptide receptor agonists (GLP-1RAs) showed a beneficial effect on NAFLD, although the underpinning mechanisms remain unclear due to their pleiotropic effects.
Khaoula Errafii, Olfa Khalifa, Neyla S. Al-Akl, Abdelilah Arredouani   +3 more
doaj   +1 more source

Differential effects of steroids and retinoids on bovine myelopoiesis in vitro [PDF]

, 2004
Pregnancy and parturition are associated with physiological changes caused by steroid hormones. Alterations in number, maturity, and function of polymorphonuclear leukocytes observed in dairy cows at parturition suggest a common causative relationship ...
Burvenich, Christian, Duchateau, Luc, Meyer, Evelyne, VAN MERRIS, V   +3 more
core   +1 more source

Retinoid X receptors: X-ploring their (patho)physiological functions [PDF]

Cell Death & Differentiation, 2004
Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function. This places RXR in the crossroad of multiple distinct biological pathways.
Szántó, Attila, Narkar, Vihang, Shen, Qiang, Uray, Iván Péter, Davies, Peter J. A., Nagy, László   +5 more
openaire   +3 more sources

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Brain : a journal of neurology, 2015
The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation.
M. Natrajan, A. G. de la Fuente, A. Crawford, E. Linehan, Vanessa Núñez, Kory R. Johnson, Tianxia Wu, D. Fitzgerald, M. Ricote, B. Bielekova, R. Franklin   +10 more
semanticscholar   +1 more source

Association of potential salivary biomarkers with diabetic retinopathy and its severity in type-2 diabetes mellitus: a proteomic analysis by mass spectrometry [PDF]

PeerJ, 2016
Aim/hypothesis: The aim of our study was to characterize the human salivary proteome and determine the changes in protein expression in two different stages of diabetic retinopathy with type-2 diabetes mellitus: (1) with non-proliferative diabetic ...
Chin Soon Chee, Khai Meng Chang, Mun Fai Loke, Voon Pei Angela Loo, Visvaraja Subrayan   +4 more
doaj   +2 more sources