Results 51 to 60 of about 155,897 (329)

Regulation of Dystroglycan Gene Expression in Early Myoblast Differentiation

Frontiers in Cell and Developmental Biology, 2022
Dystroglycan, a component of the dystrophin-associated glycoprotein complex, connects the extracellular matrix and cytoskeleton to maintain muscle membrane integrity.
Munerah Hamed, Jihong Chen, Qiao Li, Qiao Li   +3 more
doaj   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +2 more sources

Adaptive evolution of the Retinoid X receptor in vertebrates

Genomics, 2012
Retinoid X receptors (RXR) are transcription factors with important roles in development, reproduction, homeostasis, and cell differentiation. Different types of vertebrate RXRs (α (RXRA), ß (RXRB) and γ (RXRG)) have arisen from multiple duplication events.
Miguel M. Santos, Rute R. da Fonseca, L. Filipe C. Castro, Agostinho Antunes, Siby Philip, Vitor Vasconcelos, Maria Armanda Reis-Henriques   +6 more
openaire   +3 more sources

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

Journal of Cell Biology, 2015
Activation of retinoid X receptor γ and vitamin D receptor (VDR) heterodimer via vitamin D enhances oligodendrocyte progenitor differentiation, whereas blocking VDR impairs differentiation and myelination ex vivo.
A. G. de la Fuente, O. Errea, P. van Wijngaarden, G. Gonzalez, C. Kerninon, Andrew A Jarjour, H. Lewis, Clare A. Jones, B. Nait-Oumesmar, Chao Zhao, Jeffrey K. Huang, C. ffrench-Constant, R. Franklin   +12 more
semanticscholar   +1 more source

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]

, 2014
Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core   +1 more source

Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cholestasis is the major cause of the accumulation of bile acids and results in liver damage, fibrosis, and failure. A growing number of studies have shown that gentiopicroside is a promising prospect that may protect the liver. However,
Han Han, Lili Xu, Kai Xiong, Tong  Zhang, Zhengtao Wang   +4 more
doaj   +1 more source

Chromosomal Localization of the Human Retinoid X Receptors

Genomics, 1994
The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, we report high-resolution localization of the human RXR genes within cytogenetic bands and also ...
Alexandru Almasan, Ronald M. Evans, Estelita S. Ong, Geoffrey M. Wahl, David J. Mangelsdorf   +4 more
openaire   +3 more sources

Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression

Journal of Neuroscience, 2015
α-synuclein, a protein enriched in Lewy bodies and highly implicated in neurotoxicity in Parkinson's disease, is distributed both at nerve terminals and in the cell nucleus.
N. Volakakis, K. Tiklová, M. Decressac, Maria Papathanou, B. Mattsson, L. Gillberg, A. Nobre, A. Björklund, T. Perlmann   +8 more
semanticscholar   +1 more source

The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Receptors

Canadian Journal of Gastroenterology, 2003
The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
doaj   +1 more source

Targeted therapy for breast cancer prevention. [PDF]

, 2013
With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer.
Brown, Powel H, den Hollander, Petra, Savage, Michelle I   +2 more
core   +2 more sources