Results 131 to 140 of about 122,450 (299)

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin   +10 more
wiley   +1 more source

Synergistic Steatosis Induction in Mice: Exploring the Interactions and Underlying Mechanisms between PFOA and Tributyltin

Cells
This study explores the impact of environmental pollutants on nuclear receptors (CAR, PXR, PPARα, PPARγ, FXR, and LXR) and their heterodimerization partner, the Retinoid X Receptor (RXR).
Yannick Dauwe, Lucile Mary, Fabiana Oliviero, Louise Dubois, Elodie Rousseau-Bacquie, Jelskey Gomez, Véronique Gayrard, Laïla Mselli-Lakhal   +7 more
doaj   +1 more source

2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors.

Endocrinology, 2023
Ren XM, Chang RC, Huang Y, Amorim Amato A, Carivenc C, Grimaldi M, Kuo Y, Balaguer P, Bourguet W, Blumberg B.   +9 more
europepmc   +1 more source

Gene transcription of the retinoid X receptor α (RXRα) is regulated by fatty acids and hormones in rat hepatic cells [PDF]

, 1998
Hilde Hermansen Steineger, Borghild Arntsen, Øystein Spydevold, Hilde Nebb Sørensen   +3 more
openalex   +1 more source

Pharmacokinetics, Bioequivalence, and Safety Studies of Crisaborole Ointment in Healthy Chinese Subjects

Clinical Pharmacology in Drug Development, Volume 14, Issue 8, Page 614-620, August 2025.
Abstract The aim of this study was to evaluate the bioequivalence and safety of a single application of crisaborole ointment to test formulation and reference formulation in healthy subjects under fasting conditions. A total of 32 subjects were included and divided into 2 groups (test‐reference; reference‐test).
Yanchao Wang, Xiaofei Zhao, Taixin Wang, Luning Xiong, Xiujuan Liu, Jing Pan, Wen Yin, Chao Zhang, Jining Dong, Kexin Zhao   +9 more
wiley   +1 more source

Expression of retinoid receptors during rabbit lung development

Animal, 2007
Rabbit lung is often used to study the pathophysiology of some congenital anomalies affecting the lung because its development is very comparable with that of human.
K. Coste, D. Gallot, G. Marceau, J. Jani, J. Deprest, A. Labbé, D. Lémery, V. Sapin   +7 more
doaj  

Identification of a Retinoid/Chicken Ovalbumin Upstream Promoter Transcription Factor Response Element in the Human Retinoid X Receptor γ2 Gene Promoter [PDF]

, 1997
Philip M. Barger, Daniel P. Kelly
openalex   +1 more source

Microbiota–Host Interactions: Exploring Their Dynamics and Contributions to Human Diseases

MicrobiologyOpen, Volume 14, Issue 4, August 2025.
Bacterial dysbiosis results from microbiota imbalances, diet, lifestyle, and other factors that lead to conditions such as IBS, IBD, acne, dermatitis, and dental diseases. The current therapeutic approaches include probiotics, prebiotics, synbiotics, microbiota transplantation, and phage therapy.
Siau Wui Chin, Zheng Yao Low, Wei Qi Tan, Adzzie Shazleen Azman   +3 more
wiley   +1 more source

The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ

Cell Communication and Signaling
The human retinoid X receptor γ (hRXRγ) is one of three characterized RXR subtypes, transcription factors belonging to the nuclear receptor superfamily. All RXR subtypes share nearly identical structural elements, including a conserved DNA-binding domain,
Katarzyna Sołtys, Krzysztof Skowronek, Dominika Bystranowska, Krzysztof Wycisk, Andrzej Ożyhar   +4 more
doaj   +1 more source

Overexpressed Activated Retinoid X Receptors Can Mediate Growth Inhibitory Effects of Retinoids in Human Carcinoma Cells [PDF]

, 1998
Haisu Wan, Marcia I. Dawson, Waun Ki Hong, Reuben Lotan   +3 more
openalex   +1 more source