Results 141 to 150 of about 122,450 (299)

A coarse‐grained model for disordered proteins under crowded conditions

Protein Science, Volume 34, Issue 8, August 2025.
Abstract Macromolecular crowding may strongly affect the dynamics and function of proteins, with intrinsically disordered proteins being particularly sensitive to their crowded environment. To understand the influences of crowding on chain compaction and phase separation (PS) behavior of disordered proteins, both experiments with synthetic crowders ...
Arriën Symon Rauh, Giulio Tesei, Kresten Lindorff‐Larsen   +2 more
wiley   +1 more source

Ligand-dependent enhancement of human antithrombin gene expression by retinoid X receptor α and thyroid hormone receptor β [PDF]

, 1996
René W L M Niessen, Farhad Rezaee, Pieter H. Reitsma, Marjolein PETERS, Jan J. M. de Vijlder, Augueste STURK   +5 more
openalex   +1 more source

Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises

Molecular Ecology Resources, Volume 25, Issue 6, August 2025.
ABSTRACT Genomic incompatibilities and differential ecological adaptation are thought to be fundamental mechanisms of speciation. In this study, we generated a chromosome‐scale reference genome and annotation for Gopherus morafkai , the Sonoran Desert tortoise, and conducted a detailed analysis of genes under positive selection with its sister species,
Sarah M. Baty, Raúl Araya‐Donoso, Avery Paulsen, Avery Williams, Dale F. DeNardo, Kenro Kusumi, Greer A. Dolby   +6 more
wiley   +1 more source

Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors

, 1993
Evan D. Rosen, Eric Beninghof, Ronald J. Koenig   +2 more
openalex   +1 more source

Differential 9-cis-Retinoic Acid-dependent Transcriptional Activation by Murine Retinoid X Receptor α (RXRα) and RXRβ [PDF]

, 1996
Paul L. Hallenbeck, Saverio Minucci, Roland E. Lippoldt, M. Phyillaier, Valerie J. Horn, Keiko Ozato, Vera M. Nikodem   +6 more
openalex   +1 more source

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, Volume 182, Issue 16, Page 3744-3766, August 2025.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Therapeutic potential of nuclear receptor agonists in Alzheimer's disease

Journal of Lipid Research, 2017
Alzheimer's disease (AD) is characterized by an extensive accumulation of amyloid-β (Aβ) peptide, which triggers a set of deleterious processes, including synaptic dysfunction, inflammation, and neuronal injury, leading to neuronal loss and cognitive ...
Miguel Moutinho, Gary E. Landreth
doaj  

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

British Journal of Pharmacology, Volume 182, Issue 15, Page 3411-3427, August 2025.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou, Guoming Li, Ruixiang Tan, Guodong Wu, Changsheng Deng   +4 more
wiley   +1 more source

Vitamin D Supplementation Improves Muscle Mass, Physical Function, and Quality of Life in Patients With Degenerative Lumbar Disease

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT Degenerative lumbar disease is a significant contributor to acute or chronic musculoskeletal issues in the elderly, often associated with low serum 25‐hydroxyvitamin D (25(OH)D) levels. The effect of vitamin D2 supplementation on muscle mass, strength, and physical performance remains unclear.
Sinsuda Dechsupa, Wicharn Yingsakmongkol, Worawat Limthongkul, Weerasak Singhatanadgige, Suvichada Assawakosri, Sittisak Honsawek   +5 more
wiley   +1 more source

Retinoic acids and nuclear receptor signaling in liver development: Pathogenic roles in liver diseases

Pediatric Discovery
Retinoic acid (RA) serves as a metabolic intermediate of vitamin A. It plays a crucial physiological role in regulating cell proliferation, differentiation, apoptosis, embryonic development, and immunomodulation.
Wen Jia, Yang Bi
doaj   +1 more source