Results 51 to 60 of about 121,393 (276)

Induced differentiation of acute myeloid leukemia cells by activation of Retinoid X and Liver X Receptors

Leukemia, 2013
Use of all-trans retinoic acid (ATRA) as a differentiation agent has been limited to acute promyelocytic leukemia (APL) as non-APL leukemias are insensitive to ATRA.
P. V. Sanchez, Spencer T. Glantz, S. Scotland, M. Kasner, M. Carroll   +4 more
semanticscholar   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source

Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats [version 2; referees: 1 approved, 2 approved with reservations]

F1000Research, 2016
Alzheimer's disease (AD) is characterized pathologically by the presence of amyloid plaques and neurofibrillary tangles. The amyloid hypothesis contends that the abnormal accumulation of Aβ, the principal component of amyloid plaques, plays an essential ...
Songli Wang, Paul Wen, Stephen Wood
doaj   +1 more source

Dimerization with Retinoid X Receptors Promotes Nuclear Localization and Subnuclear Targeting of Vitamin D Receptors*

Journal of Biological Chemistry, 2000
The vitamin D receptor (VDR) acts as heterodimer with the retinoid X receptor α (RXR) to control transcriptional activity of target genes. To explore the influence of heterodimerization on the subcellular distribution of these receptors in living cells ...
K. Prüfer, A. Rácz, Grace C. Lin, J. Bársony   +3 more
semanticscholar   +1 more source

Maximal use of 0.05% topical isotretinoin in patients with congenital ichthyosis results in low systemic exposure

British Journal of Clinical Pharmacology, EarlyView.
Abstract Congenital ichthyoses (CI) are rare, inherited skin disorders characterized by hyperkeratosis, scaling and fissuring that significantly impair patients' quality of life. Treatment options are limited, with systemic retinoids reserved for severe cases owing to their adverse effect profile.
Holm Schneider, Christopher G. Bunick, Kathrin Hillmann, Thy N. Huynh, Steven Kempers, Nicolai Peschel, Ulrike Blume‐Peytavi, Joyce M. C. Teng, Alan M. Mendelsohn, John Stinson, Lara Wine Lee   +10 more
wiley   +1 more source

Specific Activation of Retinoic Acid Receptors (RARs) and Retinoid X Receptors Reveals a Unique Role for RARγ in Induction of Differentiation and Apoptosis of S91 Melanoma Cells*

Journal of Biological Chemistry, 1997
Retinoic acid (RA) and 9-cis-RA induce growth arrest and differentiation of S91 melanoma cells. RA activates retinoic acid receptors (RARs), whereas 9-cis-RA activates both RARs and retinoid X receptors (RXRs).
R. Spanjaard, M. Ikeda, Patricia J. Lee, Bruno Charpentier, W. Chin, T. Eberlein   +5 more
semanticscholar   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, EarlyView.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

Roles of distinct nuclear receptors in diabetic cardiomyopathy

Frontiers in Pharmacology
Diabetes mellitus induces a pathophysiological disorder known as diabetic cardiomyopathy and may eventually cause heart failure. Diabetic cardiomyopathy is manifested with systolic and diastolic contractile dysfunction along with alterations in unique ...
Yangyang Zheng, Yongji Xu, Li Ji, Wenqing San, Danning Shen, Qianyou Zhou, Guoliang Meng, Jiahai Shi, Yun Chen   +8 more
doaj   +1 more source

Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil[S]

Journal of Lipid Research, 2012
Omega-3-PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are associated with prevention of various aspects of metabolic syndrome.
Peter J. Gillies, Sujata K. Bhatia, Leigh A Belcher, Daniel B. Hannon, Jerry T. Thompson, John P. Vanden Heuvel   +5 more
doaj   +1 more source