Results 71 to 80 of about 122,450 (299)

Nuclear receptors in neurodegenerative diseases

Neurobiology of Disease, 2014
Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders.
Rebecca Skerrett, Tarja Malm, Gary Landreth   +2 more
doaj  

Epigenetic Silencing of Cellular Retinol-Binding Proteins in Nasopharyngeal Carcinoma

Neoplasia: An International Journal for Oncology Research, 2005
Aberrant retinoid signaling in human cancers is extending from the nucleus to the cytoplasm. Recently, we have demonstrated frequent epigenetic inactivation of a retinoic acid receptor (RAR), RARβ2, in nasopharyngeal carcinoma (NPC).
Joseph Kwong, Kwok-Wai Lo, Lillian Shuk-Nga Chow, Ka-Fai To, Kwong-Wai Choy, Franky Leung Chan, Samuel C. Mok, Dolly P. Huang   +7 more
doaj   +1 more source

New ligands of the Cellular Retinoic Acid-Binding Protein 2 (CRABP2) suggest a role for this protein in chromatin remodeling

Revista de Ciências Farmacêuticas Básica e Aplicada, 2014
Retinoic acid (RA) regulates the transcription of a series of genes involved in cell proliferation, differentiation and apoptosis by binding to the RA Receptor (RAR) and Retinoid X Receptor (RXR) heterodimers.
Daniella de Barros Rossetto, Eric Nishimura Kiyomoto, Carlos Eduardo Brantis de Carvalho, Cleslei Fernando Zanelli, Sandro Roberto Valentini   +4 more
doaj   +2 more sources

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis.

Carcinogenesis, 2004
Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are important in regulating the development, growth and differentiation of cells and have inhibitory effects on non-small cell lung cancer (NSCLC) cell growth. A comprehensive analysis of all
J. Brabender, R. Metzger, D. Salonga, K. Danenberg, P. Danenberg, A. Hölscher, P. Schneider   +6 more
semanticscholar   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

The Tetramerization Region of the Retinoid X Receptor Is Important for Transcriptional Activation by the Receptor [PDF]

Journal of Biological Chemistry, 1997
The retinoid X receptor (RXR), a member of the superfamily of hormone nuclear receptors, is a ligand-inducible transcription factor that is activated by the vitamin A derivative 9-cis-retinoic acid. We previously showed that RXR self-associates into tetramers with a high affinity and that ligand binding induces rapid dissociation of receptor tetramers ...
Sander Kersten, Noa Noy, Peter R. Reczek
openaire   +3 more sources

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Low-resolution molecular models reveal the oligomeric state of the PPAR and the conformational organization of its domains in solution.

PLoS ONE, 2012
The peroxisome proliferator-activated receptors (PPARs) regulate genes involved in lipid and carbohydrate metabolism, and are targets of drugs approved for human use.
Amanda Bernardes, Fernanda A H Batista, Mario de Oliveira Neto, Ana Carolina M Figueira, Paul Webb, Daniel Saidemberg, Mario S Palma, Igor Polikarpov   +7 more
doaj   +1 more source

Thyroid hormone receptor variant alpha2. Role of the ninth heptad in dna binding, heterodimerization with retinoid X receptors, and dominant negative activity.

Journal of Biological Chemistry, 1996
Thyroid hormone receptors bind DNA with highest affinity as heterodimers with retinoid X receptors, and such heterodimers generally are thought to be the biological mediators of thyroid hormone action. An alternative splice product of the thyroid hormone
Y. Yang, M. Burgos-Trinidad, Y. Wu, R. Koenig   +3 more
semanticscholar   +1 more source