Results 21 to 30 of about 55,482 (284)

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate. [PDF]

open access: yes, 2017
The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates ...
Fain, Gordon L   +6 more
core   +1 more source

Enhancement of Efficacy of Retinoids through Enhancing Retinoid-Induced RAR Activity and Inhibiting Hydroxylation of Retinoic Acid, and Its Clinical Efficacy on Photo-Aging

open access: yesPharmaceutics, 2022
Retinoids, one of the most robust bioactive materials, have been widely used to improve various dermatological and pathological conditions. The body has an endogenous mechanism that modulates the exogenous retinoid above physiological concentrations ...
Seongsu Kang   +4 more
doaj   +1 more source

Restoring Retinal Function in a Mouse Model of Hereditary Blindness [PDF]

open access: yes, 2005
Moore discusses a new study showing rescue of photoreceptor function using gene and drug therapies in a mouse model of Leber congenital ...
Moore, Tony
core   +4 more sources

Revival of the Russian chemical industry during the Soviet period (1917–1927). Part 4

open access: yesРазработка и регистрация лекарственных средств, 2022
The fourth chapter presents V. N. Ipatiev's memoirs about the preparation and celebration of the 200th anniversary of the Russian Academy of Sciences and the next Mendeleev Congress.
K. S. Guzev
doaj  

The Role of the Decrees of Peter the Great in the Formation and Development of Russian Pharmacy. Part 2

open access: yesРазработка и регистрация лекарственных средств, 2023
The second part of the article presents the next steps of Peter the Great to improve the functioning of the pharmacy service in Russia. To improve the management of the nascent pharmacy service, the Emperor established the Main Pharmacy in the ...
K. S. Guzev
doaj  

RPB4 and pathogenesis of diabetes [PDF]

open access: yes, 2007
Obesity is an important risk factor for a number of chronic diseases that impose a huge burden on individuals and society. Recently it has become clear that adipose tissue-secreted products may play a significant role in mediating many obesity-related ...
Kumar, Sudhesh   +1 more
core   +1 more source

Dermatology [PDF]

open access: yes, 2004
Dermatology continues to develop at a steady pace. In the past few years there have been exciting advances in our understanding of skin structure and function in health and disease and progress in genetics, epidemiology, immunology, pharmacology and ...
Boffa, Michael J.
core   +1 more source

Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra. [PDF]

open access: yes, 2017
Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia.1 Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in
Barbareschi   +9 more
core   +1 more source

Retinoids for prevention and treatment of actinic keratosis [PDF]

open access: yesAnais Brasileiros de Dermatologia, 2013
Actinic keratosis is a common cause of dermatological consultations and it presents a strong association with squamous cell carcinoma. Many substances are used for treatment and prevention, such as retinoids.
Mayra Ianhez   +3 more
doaj   +1 more source

Differential effects of steroids and retinoids on bovine myelopoiesis in vitro [PDF]

open access: yes, 2004
Pregnancy and parturition are associated with physiological changes caused by steroid hormones. Alterations in number, maturity, and function of polymorphonuclear leukocytes observed in dairy cows at parturition suggest a common causative relationship ...
Burvenich, Christian   +3 more
core   +1 more source

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