Results 41 to 50 of about 16,020 (245)
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
Mobile DNA, 2018 Background The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. In patients, inactivating mutations
Alexandra Herrmann +6 more
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Cytological features of penaut genome [PDF]
, 2017 The genus Arachis is composed of 82 species (Krapovickas and Gregory 1994; Valls and Simpson 2005; Valls et al 2013; Santana and Valls 2015) mainly distributed within a large region of South America, which extends from the eastern foothills of the Andes ...
Chalup, Laura María Isabel +6 more
core +1 more source
Generalized nuclear localization of retroelement transcripts
Mobile DNA, 2022 Abstract Background LINE-1s, Alus and SVAs are the only retrotransposition competent elements in humans. Their mobilization followed by insertional mutagenesis is often linked to disease. Apart from these rare integration events, accumulation of retrotransposition intermediates in the cytoplasm is potentially pathogenic ...
Simanti Das +2 more
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Retroelement origins of pre‐mRNA splicing [PDF]
WIREs RNA, 2020 AbstractRecent cryo‐EM structures of a group II intron caught in the process of invading DNA have given new insight into the mechanisms of both splicing and retrotransposition. Conformational dynamics involving the branch‐site helix domain VI are responsible for substrate exchange between the two steps of splicing.
Daniel B. Haack, Navtej Toor
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American Journal of Perinatology Reports, 2018 Objective The retroviral genes encoding Syncytin-1 (SYN1) and Syncytin-2 (SYN2) are epigenetically regulated, uniquely expressed in the placenta and critical to placental function.
Sami P. Makaroun, Katherine P. Himes
doaj +1 more source
Telomeres in Evolution and Development from Biosemiotic Perspective [PDF]
, 2007 Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
core +3 more sources
Giant reverse transcriptase-encoding transposable elements at telomeres [PDF]
, 2017 Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Oxford University Press for personal use, not for redistribution.
Arkhipova, Irina R. +2 more
core +1 more source
COVID-19, Retroelements, and Aging [PDF]
Advances in Gerontology, 2021 The review presents an analysis of the scientific data on the characteristics of COVID-19 from the perspective of potential interactions between the virus and the host genome retroelements. According to global statistical data, severe COVID-19 with immune-system hyperactivity is observed mainly in elderly people.
Mustafin, R. N., Khusnutdinova, E. K.
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Retrotransposon-Encoded Reverse Transcriptase in the Genesis, Progression and Cellular Plasticity of Human Cancer [PDF]
, 2011 LINE-1 (Long Interspersed Nuclear Elements) and HERVs (Human Endogenous Retroviruses) are two families of autonomously replicating retrotransposons that together account for about 28% of the human genome.
Matteucci, C +2 more
core +2 more sources
Efficient retroelement-mediated DNA writing in bacteria [PDF]
Cell Systems, 2020 AbstractThe ability to efficiently and dynamically change information stored in genomes would enable powerful strategies for studying cell biology and controlling cellular phenotypes. Current recombineering-mediated DNA writing platforms in bacteria are limited to specific laboratory conditions, often suffer from suboptimal editing efficiencies, and ...
Farzadfard, Fahim +3 more
openaire +3 more sources