Results 221 to 230 of about 399,425 (291)

Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease.

, 1992
Debasish Chattopadhyay, David Evans, Martin R. Deibel, Anne F. Vosters, F. M. ECKENRODE, Howard Einspahr, John O. Hui, A G Tomasselli, Heidi A. Zürcher-Neely, R.L. Heinrikson   +9 more
openalex   +1 more source

Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function [PDF]

, 1991
Naoko Tanese, Alice Telesnitsky, Stephen P. Goff   +2 more
openalex   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

High prevalence of reverse transcriptase inhibitors associated resistance mutations among people living with HIV on dolutegravir-based antiretroviral therapy in Francistown, Botswana. [PDF]

J Antimicrob Chemother
Choga OT, Lemogang GM, Choga WT, Muzanywa G, Shadreck TM, Ralegoreng C, Maruapula D, Moraka NO, Koofhethile CK, Mokgethi PT, Seru K, Zuze BJL, Montshosi P, Gobe I, Motswaledi MS, Musonda R, Mbulawa MB, Makhema J, Shapiro R, Lockman S, Chebani T, Nawa J, Bochena L, Moyo S, Gaseitsiwe S.   +24 more
europepmc   +1 more source

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

iMeta, EarlyView.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen, Wenxin Qu, Mengdi Song, Tianyu Zhang, Chang Liu, Xiaofeng Shi, Xinxin Xu, Jingjing Jiang, Liguo Ding, Fangyu Mo, Zheying Mao, Mingzhu Huang, Ziye Xu, Jiaye Chen, Enhui Shen, Jian Ruan, Jiong Liu, Michael P. Timko, Yu Chen, Longjiang Fan, Shufa Zheng, Yongcheng Wang   +21 more
wiley   +1 more source

DNA polymerase ζ has robust reverse transcriptase activity relative to other cellular DNA polymerases. [PDF]

J Biol Chem
Mayle R, Holloman WK, O'Donnell ME.
europepmc   +1 more source

Structural and biochemical characterization of cauliflower mosaic virus reverse transcriptase. [PDF]

J Biol Chem
Prabaharan C, Figiel M, Szczepanowski RH, Skowronek K, Zajko W, Thangaraj V, Chamera S, Nowak E, Nowotny M.   +8 more
europepmc   +1 more source

Pharmacokinetics of Atorvastatin and Metformin after Coadministration with Islatravir in Healthy Adults

The Journal of Clinical Pharmacology, EarlyView.
Abstract Islatravir, a deoxyadenosine analog that inhibits HIV‐1 replication by multiple mechanisms of action, including reverse transcriptase translocation inhibition, is being developed for use in HIV‐1 treatment. People living with HIV often have comorbidities, such as dyslipidemia or type 2 diabetes mellitus, necessitating long‐term concomitant ...
Jacqueline B. McCrea, Munjal Patel, Yang Liu, Ryan Vargo, Rose Witter, Andrew Litovsky, S. Aubrey Stoch, Marian Iwamoto, Randolph P. Matthews   +8 more
wiley   +1 more source

Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus. [PDF]

Vet World
Longa-Bobadilla V, Ormeño-Vásquez P, Criollo-Orozco M, Tataje-Lavanda L, Huamán-Gutierrez K, Montalván Á, Zimic M, Fernández-Sanchez M, Fernández-Díaz M.   +8 more
europepmc   +1 more source

Elevated Blood Hemoglobin in Different Cavefish Populations Evolves Through Diverse Hemoglobin Gene Expression Patterns

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Distinct populations of the cave‐dwelling fish, Astyanax mexicanus, have adapted to low oxygen through the upregulation of hemoglobin gene expression. This work demonstrates that diverse transcriptomic mechanisms have evolved for hypoxic adaptation via different hemoglobin genes.
Tyler E. Boggs, Joshua B. Gross
wiley   +1 more source