A novel variant of telomerase reverse transcriptase (TERT) associated with risk of glioma in a Korean population. [PDF]
Lim HY+5 more
europepmc +1 more source
Case Report: Hypomyelinating Leukodystrophy Type 20 (HLD20) With Novel CNP Gene Variant
ABSTRACT This case report describes a child with hypomyelinating leukodystrophy type 20 (HLD20), a rare neurodegenerative disorder characterized by impaired myelin formation. The patient presented with multiple neurodevelopmental abnormalities, including delayed motor milestones, seizures, and abnormal facial features.
Malak Alghamdi+7 more
wiley +1 more source
Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens. [PDF]
Hullahalli K+5 more
europepmc +1 more source
Premature strand transfer by the HIV-1 reverse transcriptase during strong-stop DNA synthesis [PDF]
Bep Klaver, Ben Berkhout
openalex +1 more source
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani+6 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Hepatology, EarlyView.
Robert J. Fontana+6 more
wiley +1 more source
An Exploratory Pharmacogenetic Pilot Study of Two Reverse Transcriptase Inhibitors, Tenofovir Alafenamide Fumarate and Tenofovir Disoproxil Fumarate. [PDF]
Murrell DE+8 more
europepmc +1 more source
Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H [PDF]
Alice Telesnitsky+2 more
openalex +1 more source
Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy
Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali+7 more
wiley +1 more source
Strand displacement synthesis capability of Moloney murine leukemia virus reverse transcriptase [PDF]
Samuel H. Whiting, James J. Champoux
openalex +1 more source