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Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration. [PDF]
Cancer BiomarkXiao X +10 more
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Current Protocols in Cell Biology, 2008
AbstractThe Rho GTPase family of signaling proteins controls a wide range of highly dynamic cellular processes. Activation of Rho GTPases can be investigated and quantified in cell extracts using so‐called pull‐down assays. Proteins that bind specifically to the activated form of the Rho GTPase are used to capture it onto a bead support.
Harry Mellor
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AbstractThe Rho GTPase family of signaling proteins controls a wide range of highly dynamic cellular processes. Activation of Rho GTPases can be investigated and quantified in cell extracts using so‐called pull‐down assays. Proteins that bind specifically to the activated form of the Rho GTPase are used to capture it onto a bead support.
Harry Mellor
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Experimental Cell Research, 1999
Rho GTPases regulate many important processes in all eukaryotic cells, including the organization of the actin cytoskeleton, gene transcription, cell cycle progression, and membrane trafficking. Their activity is regulated by signals originating from different classes of surface receptors including G-protein-coupled receptors, tyrosine kinase receptors,
L, Kjoller, A, Hall
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Rho GTPases regulate many important processes in all eukaryotic cells, including the organization of the actin cytoskeleton, gene transcription, cell cycle progression, and membrane trafficking. Their activity is regulated by signals originating from different classes of surface receptors including G-protein-coupled receptors, tyrosine kinase receptors,
L, Kjoller, A, Hall
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BioFactors, 2013
AbstractRho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in
Li, Hui +3 more
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AbstractRho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in
Li, Hui +3 more
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Nature Reviews Cancer, 2002
The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP. This is then exchanged for GTP and the cycle is repeated. The switching between these two states regulates a wide range of cellular processes.
Erik, Sahai, Christopher J, Marshall
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The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP. This is then exchanged for GTP and the cycle is repeated. The switching between these two states regulates a wide range of cellular processes.
Erik, Sahai, Christopher J, Marshall
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2005
The Rho (Ras-homologous) family of proteins constitutes a major branch of the Ras superfamily of small GTPases, and is evolutionarily conserved across several phyla. Thus far, 25 members have been identified, and these may be divided into 6 subfamilies based on amino acid sequence identity, structural motifs, and biological function.
Pinella, Buongiorno, Bharati, Bapat
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The Rho (Ras-homologous) family of proteins constitutes a major branch of the Ras superfamily of small GTPases, and is evolutionarily conserved across several phyla. Thus far, 25 members have been identified, and these may be divided into 6 subfamilies based on amino acid sequence identity, structural motifs, and biological function.
Pinella, Buongiorno, Bharati, Bapat
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Current Opinion in Cell Biology, 1999
The Rho GTPases are simple enzymes with complex roles in regulating cell morphology, gene transcription, cell cycle progression, apoptosis and tumour progression. The picture has been further complicated by the steady rise in the number of known Rho GTPases as well as in the number of known regulators and target proteins of these GTPases.
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The Rho GTPases are simple enzymes with complex roles in regulating cell morphology, gene transcription, cell cycle progression, apoptosis and tumour progression. The picture has been further complicated by the steady rise in the number of known Rho GTPases as well as in the number of known regulators and target proteins of these GTPases.
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Biochemical Society Transactions, 2012
Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton,
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Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton,
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2016
The Ras-homology (Rho) GTPases were initially linked to regulation of actin cytoskeletal architecture, maintenance of cell shape and polarity, and to cell migration. Subsequent studies have shown that Rho GTPases are involved in highly diverse cellular and biological functions, many of which contribute to tumorigenesis.
Lukey, M. J., Cerione, R. A.
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The Ras-homology (Rho) GTPases were initially linked to regulation of actin cytoskeletal architecture, maintenance of cell shape and polarity, and to cell migration. Subsequent studies have shown that Rho GTPases are involved in highly diverse cellular and biological functions, many of which contribute to tumorigenesis.
Lukey, M. J., Cerione, R. A.
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Rho GTPase function in tumorigenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their
Karlsson, R +3 more
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