Results 161 to 170 of about 251,198 (269)
Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Qiaowei Zhang +7 more
wiley +1 more source
This study identifies a high‐risk neuroblastoma subtype defined by MYCN amplification and an “immune desert” tumor microenvironment. We uncover novel lymphocyte‐specific immunosuppressive networks, including T cell dysfunction and a MYC‐driven B cell hub, revealing potential therapeutic targets.
Jia‐Jian Hu +5 more
wiley +1 more source
This is a Sigma Gamma Rho keychain. It is clear plexiglass that has been cut into a rectangle. It has the sorority's Greek letters etched into the surface.Sigma Gamma Rho was founded at Butler University in 1922; in 1929 the organization was established ...
Sigma Gamma Rho Sorority, Inc.
core +1 more source
Retraction: Smoothened regulates migration of fibroblast-like synoviocytes in rheumatoid arthritis <i>via</i> activation of Rho GTPase signaling. [PDF]
Frontiers Editorial Office.
europepmc +1 more source
The role of Rho GTPase family in cochlear hair cells and hearing. [PDF]
Dai YB, Gao X, Liu D, Gong J.
europepmc +1 more source
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
Promotive effects of 830-nm Photobiomodulation on corneal epithelial wound healing and rho-gtpase expression in a rat alkali burn model. [PDF]
Jang E, Kim H, Cho K.
europepmc +1 more source
Unveiling the Functional Role of KIF21B in Microglia Inflammatory Response
Microglia express KIF21B in both sexes. KIF21B binds to microglia cytoskeleton; inflammation alters such interaction promoting a phagocytic state in females. In male microglia KIF21B modulates migration. ABSTRACT Microglia are brain immune cells that maintain homeostasis and respond to injury, changing cell morphology to drive inflammation, migration ...
Danny Ganchala +6 more
wiley +1 more source
C-terminal S-acylation governs membrane distribution, interaction dynamics and function of a plant Rho GTPase. [PDF]
Akerman A +5 more
europepmc +1 more source
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang +16 more
wiley +1 more source

