Results 121 to 130 of about 72,889 (250)

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning

The EMBO Journal
Rho GTPases form plasma membrane-associated patterns that control the cytoskeleton during cell division, morphogenesis, migration, and wound repair.
Michael C Armstrong, Yannic R Weiß, Lila E Hoachlander-Hobby, Ankit A Roy, Ilaria Visco, Alison Moe, Adriana E Golding, Scott D Hansen, William M Bement, Peter Bieling   +9 more
doaj   +1 more source

DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression

Stem Cell Research & Therapy, 2018
Background DNA topoisomerase IIβ (topo IIβ) is known to regulate neural differentiation by inducing the neuronal genes responsible for critical neural differentiation events such as neurite outgrowth and axon guidance.
Merve Zaim, Sevim Isik
doaj   +1 more source

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]

, 2002
We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
core  

Role of ZNF652 in Regulating Hepatocellular Carcinoma Cell Proliferation and Apoptosis via the circRHOT1/SLC38A6 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is a heterogeneous malignancy characterized by high mortality rates. This article presents a discussion of the role of ZNF652 in HCC cell proliferation and apoptosis, thereby identifying a new target for HCC treatment. The expression levels of ZNF652, circRHOT1, and SLC38A6 in HCC and healthy cells were analyzed.
Kang Chen, Fei‐Hu Sun, Chen Fan, Wei Ding, Hao‐Huan Tang, Lei Sun, Wei‐Tao Wang, Wei‐Dong Wang   +7 more
wiley   +1 more source

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils.

PLoS ONE, 2013
Neutrophils serve as a first line of defense in innate immunity owing in part to their ability to rapidly migrate towards chemotactic factors derived from invading pathogens.
Asako Itakura, Joseph E Aslan, Branden T Kusanto, Kevin G Phillips, Juliana E Porter, Paul K Newton, Xiaolin Nan, Robert H Insall, Jonathan Chernoff, Owen J T McCarty   +9 more
doaj   +1 more source

Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs. [PDF]

, 2019
Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic influences can contribute to neurological and mental disorders such as Down syndrome, Rett syndrome, and
Almenar-Queralt, Angels, DerMardirossian, Celine, Head, Brian P, Leem, Joseph, Patel, Hemal H, Patel, Piyush M, Roth, David M, Wang, Shanshan, Zhang, Zheng   +8 more
core   +1 more source

Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition

PROTEOMICS, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq, Alin Rai, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, David W. Greening, Richard J. Simpson   +6 more
wiley   +1 more source

To stay in shape and keep moving: MLL emerges as a new transcriptional regulator of Rho GTPases. [PDF]

Small GTPases, 2023
Chinchole A, Gupta S, Tyagi S.
europepmc   +1 more source