Results 151 to 160 of about 191,346 (272)

Rho GTPases: Regulation and roles in cancer cell biology

Small GTPases, 2016
Raquel B Haga, A. Ridley
semanticscholar   +1 more source

Decoding the Role of Caveolin‐1 in Morphological Diversity and Self‐Renewal of Breast Cancer Cells

Cell Proliferation, EarlyView.
The silence of caveolin‐1 (Cav‐1) reproduced the morphological evolutionary behaviour of cancer cells, which is similar to the epithelial‐mesenchymal transition process. And Cav‐1 dependent morphological changes could affect cancer cell self‐renewal capacity through maintaining the morphological stability.
Shun Li, Hongyun Duan, Lu Yang, Lingyi Jiang, Haocheng Bian, Yuqin Jiang, Yixi Zhang, Wei Yan, Qin Yang, Tingting Li, Xiang Qin, Zong‐Yuan Liu, Ningwei Sun, Kai‐fu Yang, Yiyao Liu   +14 more
wiley   +1 more source

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro. [PDF]

PLoS One, 2023
Koch D, Kho AL, Fukuzawa A, Alexandrovich A, Vanaanen KJ, Beavil A, Pfuhl M, Rees M, Gautel M.   +8 more
europepmc   +1 more source

Supplementary Figures 1-2 from Activation of Vav/Rho GTPase Signaling by CXCL12 Controls Membrane-Type Matrix Metalloproteinase–Dependent Melanoma Cell Invasion

, 2023
Rubén A. Bartolomé, Isabel Molina‐Ortiz, Rafael Samaniego, Paloma Sánchez‐Mateos, Xosé R. Bustelo, Joaquı́n Teixidó   +5 more
openalex   +2 more sources

Tumor Development in Ulcerative Colitis: Perspectives From Biomechanical Characteristics

Development, Growth &Differentiation, EarlyView.
ABSTRACT Throughout our lifespan, sustaining orderly morphological structures for ensuring proper functioning of organs is imperative. Among these structures, the extracellular matrix (ECM) plays a pivotal role in sustaining organ and tissue homeostasis. Nevertheless, elucidating the role of abnormal ECM‐induced biomechanical microenvironmental changes
Hirotaka Tao
wiley   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy. [PDF]

Cell Mol Life Sci, 2021
Raghavan A, Rao P, Neuzil J, Pountney DL, Nath S.   +4 more
europepmc   +1 more source

Cell migration: Rho GTPases lead the way.

Developmental Biology, 2004
M. Raftopoulou, A. Hall
semanticscholar   +1 more source

Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins

, 1996
Louis Lim, Christine M Hall, Clinton Monfries   +2 more
openalex   +2 more sources

Data from The V-ATPase-Inhibitor Archazolid Abrogates Tumor Metastasis via Inhibition of Endocytic Activation of the Rho-GTPase Rac1

, 2023
Romina M. Wiedmann, Karin von Schwarzenberg, Andrea Palamidessi, Laura Schreiner, Rebekka Kubisch, Johanna Liebl, Christina M. Schempp, Dirk Trauner, György Vereb, Stefan Zahler, Ernst Wagner, Rolf Müller, Giorgio Scita, Angelika M. Vollmar   +13 more
openalex   +1 more source