Results 191 to 200 of about 72,889 (250)

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Patterning of the cell cortex by Rho GTPases. [PDF]

Nat Rev Mol Cell Biol
Bement WM, Goryachev AB, Miller AL, von Dassow G.   +3 more
europepmc   +1 more source

Cross-talk-dependent cortical patterning of Rho GTPases during cell repair. [PDF]

Mol Biol Cell, 2021
Moe A, Holmes W, Golding AE, Zola J, Swider ZT, Edelstein-Keshet L, Bement W.   +6 more
europepmc   +1 more source

Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence

Cancer Innovation, Volume 5, Issue 1, February 2026.
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Rohina Alim, H. M. Kasuni Akalanka
wiley   +1 more source

Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling. [PDF]

Biochem Biophys Rep
Wåhlén E, Lennartsson J, Heldin J.
europepmc   +1 more source

Emerging roles for Rho GTPases operating at the Golgi complex. [PDF]

Small GTPases, 2021
Mysior MM, Simpson JC.
europepmc   +1 more source

Association Between Abnormal DNA Methylation and Altered Transcriptome in Muscle Five Years After Critical Illness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Critically ill patients requiring intensive care unit (ICU) admission suffer from muscle weakness that persists for years. Recently, altered RNA expression was documented in muscle of former ICU patients 5 years after critical illness that suggested disrupted mitochondrial function, disturbed lipid metabolism and fibrosis, of which ...
Ceren Uzun Ayar, Fabian Güiza, Inge Derese, Greet Van den Berghe, Ilse Vanhorebeek   +4 more
wiley   +1 more source

Transcriptional Adaptations to Muscle Loading in a Murine Model of Achilles Tendinopathy

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Achilles tendinopathy limits mobility and decreases quality of life. Physical therapy (eccentric muscle loading) improves tendon function; however, the underlying mechanisms are unknown. This study investigated the effect of load magnitude and treatment duration in a mouse Achilles tendinopathy model.
Dylan C. Easley, Bruno C. Menarim, Robert W. Grange, P. Gunnar Brolinson, Vincent M. Wang, Linda A. Dahlgren   +5 more
wiley   +1 more source

Transcriptomic Analysis Reveals That Rho GTPases Regulate Trap Development and Lifestyle Transition of the Nematode-Trapping Fungus Arthrobotrys oligospora. [PDF]

Microbiol Spectr, 2022
Yang L, Li X, Bai N, Yang X, Zhang KQ, Yang J.   +5 more
europepmc   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source