Results 31 to 40 of about 191,346 (272)
RHO GTPase family in hepatocellular carcinoma
Experimental Hematology & Oncology, 2022 RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular ...
Tiantian Wang +6 more
doaj +1 more source
Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration
Frontiers in Cellular Neuroscience, 2014 The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (~21 kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA, Rac1, and Cdc42.
Trisha eStankiewicz +4 more
doaj +1 more source
Rho GTPases and signaling networks.
Genes & Development, 1997 The Rho GTPases form a subgroup of the Ras superfamily of 20- to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions. These proteins are ubiquitously expressed across the species, from yeast to man.
L. Aelst, C. D’Souza-Schorey
semanticscholar +1 more source
RHO Family GTPases in the Biology of Lymphoma
Cells, 2019 RHO GTPases are a class of small molecules involved in the regulation of several cellular processes that belong to the RAS GTPase superfamily. The RHO family of GTPases includes several members that are further divided into two different groups: typical ...
Claudia Voena, Roberto Chiarle
doaj +1 more source
The RHO Family GTPases: Mechanisms of Regulation and Signaling
Cells, 2021 Much progress has been made toward deciphering RHO GTPase functions, and many studies have convincingly demonstrated that altered signal transduction through RHO GTPases is a recurring theme in the progression of human malignancies.
Niloufar Mosaddeghzadeh +1 more
doaj +1 more source
Implications of Rho GTPase signaling in glioma cell invasion and tumor progression
Frontiers in Oncology, 2013 Glioblastoma (GB) is the most malignant of primary adult brain tumors, characterized by a highly locally-invasive cell population, as well as abundant proliferative cells, neoangiogenesis, and necrosis.
Shannon Patricia Fortin Ensign +4 more
doaj +1 more source
Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase
Data in Brief, 2018 The Pleckstrin homology (PH) domains from the Lbc family of Rho Guanine Nucleotide Exchange Factors (Lbc RhoGEFs) interact with activated Rho family GTPases. All 7 Lbc RhoGEFs associate directly with activated Rho GTPases via their PH domains.
Zhe Chen +2 more
doaj +1 more source
Rho Family GTPases and Rho GEFs in Glucose Homeostasis
Cells, 2021 Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF ...
Polly A. Machin +3 more
doaj +1 more source
Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement
Journal of Cell Biology, 1999 Cell movement is essential during embryogenesis to establish tissue patterns and to drive morphogenetic pathways and in the adult for tissue repair and to direct cells to sites of infection.
C. Nobes, A. Hall
semanticscholar +1 more source
Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases. [PDF]
PLoS ONE, 2013 Rho family GTPases are critical regulators of many important cellular processes and the dysregulation of their activities is implicated in a variety of human diseases including oncogenesis and propagation of malignancy.
Weibing Leng +10 more
doaj +1 more source