Results 31 to 40 of about 139,231 (236)

Molecular determinants that govern scaRNA processing by Drosha/DGCR8

Biology Open, 2020
The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase.
Douglas M. McLaurin, Madelyn K. Logan, Katheryn E. Lett, Michael D. Hebert   +3 more
doaj   +1 more source

U1 small nuclear ribonucleoprotein studied by in vitro assembly. [PDF]

The Journal of cell biology, 1983
The small nuclear RNAs are known to be complexed with proteins in the cell (snRNP). To learn more about these proteins, we developed an in vitro system for studying their interactions with individual small nuclear RNA species. Translation of HeLa cell poly(A)+ mRNA in an exogenous message-dependent reticulocyte lysate results in the synthesis of snRNP ...
Thoru Pederson, E D Wieben, Steven J. Madore   +2 more
openaire   +2 more sources

Rpl13a small nucleolar RNAs regulate systemic glucose metabolism [PDF]

, 2016
Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form ribonucleoproteins to guide covalent modifications of ribosomal and small nuclear RNAs in the nucleus. Recent studies have also uncovered additional non-canonical roles for snoRNAs.
Alexis N. Harris, Christopher L. Holley, Daniel S. Ory, David E. Scherrer, David W. Piston, Dong, Feng, Fumihiko Urano, Hideji Fujiwara, Jana Mahadevan, Jean E. Schaffer, Jessie Zhang, Jiyeon Lee, Kelly D. Pyles, Krippeit-Drews, Maria S. Remedi, Porter, Rohini Sidhu, Siprashvili, Song, Stanley Ching-Cheng Huang, Suarez-Pinzon, Tiedge, Zeno Lavagnino   +23 more
core   +2 more sources

Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc.

Proceedings of the National Academy of Sciences of the United States of America, 1988
Two-dimensional gel fractionation has revealed the existence of a number (greater than or equal to 8) of additional species of HeLa cell small RNAs that have 5' trimethylguanosine cap structures and are bound by proteins containing Sm epitopes. Therefore,
Karen A. Montzka, J. Steitz
semanticscholar   +1 more source

Plant snRNP Biogenesis: A Perspective from the Nucleolus and Cajal Bodies

Frontiers in Plant Science, 2018
Small nuclear ribonucleoproteins (snRNPs) are protein–RNA complexes composed of specific snRNP-associated proteins along with small nuclear RNAs (snRNAs), which are non-coding RNA molecules abundant in the nucleus.
Misato Ohtani, Misato Ohtani
doaj   +1 more source

Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9 [PDF]

, 2018
Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons.
Cappellari, O, Cho, H-Y, Dickson, G, Kim, D, Kim, E, Kim, J-S, Koo, T, Lu-Nguyen, N B, Malerba, A, Popplewell, L   +9 more
core   +1 more source

Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. [PDF]

, 2010
The hnRNP C heterotetramer [(C1(3))C2] binds RNA polymerase II transcripts in the nucleus, along with other proteins of the core hnRNP complex, and plays an important role in mRNA biogenesis and transport.
Brunner, Jo Ellen, Ertel, Kenneth J, Rozovics, Janet M, Semler, Bert L   +3 more
core   +1 more source

Small Nuclear Ribonucleoprotein Remodeling During Catalytic Activation of the Spliceosome [PDF]

Science, 2002
Major structural changes occur in the spliceosome during its activation just before catalyzing the splicing of pre–messenger RNAs (pre-mRNAs). Whereas changes in small nuclear RNA (snRNA) conformation are well documented, little is known about remodeling of small nuclear ribonucleoprotein (snRNP) structures during spliceosome activation ...
Makarov, E.M., Makarova, O.V., Urlaub, H., Gentzel, M., Will, C.L., Wilm, M., Lührmann, R.   +6 more
openaire   +5 more sources

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Bindereif, A., Bourgeois, C.F., Clark, E.L., Dalgliesh, C., Elliott, D.J., Emami, K., Heiner, M., Leung, H.Y., Rajan, P., Robson, C.N., Stevenin, J.   +10 more
core   +7 more sources

In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing.

PLoS ONE, 2012
Coilin is known as the marker protein for Cajal bodies (CBs), subnuclear domains important for the biogenesis of small nuclear ribonucleoproteins (snRNPs) which function in pre-mRNA splicing.
Hanna J Broome, Michael D Hebert
doaj   +1 more source