Malaria infected red blood cells release small regulatory RNAs through extracellular vesicles [PDF]
, 2018 The parasite Plasmodium falciparum causes the most severe form of malaria. Cell communication between parasites is an important mechanism to control population density and differentiation.
Adapa, Swamy R. +9 more
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Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. [PDF]
Proceedings of the National Academy of Sciences, 1992 The major nuclear ribonucleoproteins (RNPs) involved in pre-mRNA processing are classified in broad terms either as small nuclear RNPs (snRNPs), which are major participants in the splicing reaction, or heterogeneous nuclear RNPs (hnRNPs), which traditionally have been thought to function in general pre-mRNA packaging.
S A, Amero +6 more
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Reconstitution of the U1 small nuclear ribonucleoprotein particle. [PDF]
Molecular and Cellular Biology, 1987 Although the U1 small nuclear ribonucleoprotein particle (snRNP) was the first mRNA-splicing cofactor to be identified, the manner in which it functions in splicing is not precisely understood. Among the information required to understand how U1 snRNP participates in splicing, it will be necessary to know its structure.
J R, Patton, R J, Patterson, T, Pederson
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Spliceosomal Small Nuclear Ribonucleoprotein Particles Repeatedly Cycle through Cajal Bodies [PDF]
Molecular Biology of the Cell, 2008 The Cajal body (CB) is a nuclear structure closely associated with import and biogenesis of small nuclear ribonucleoprotein particles (snRNPs). Here, we tested whether CBs also contain mature snRNPs and whether CB integrity depends on the ongoing snRNP splicing cycle.
Stanek, D. +7 more
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In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing.
PLoS ONE, 2012 Coilin is known as the marker protein for Cajal bodies (CBs), subnuclear domains important for the biogenesis of small nuclear ribonucleoproteins (snRNPs) which function in pre-mRNA splicing.
Hanna J Broome, Michael D Hebert
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WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. [PDF]
PLoS Biology, 2010 The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies.
Salah Mahmoudi +7 more
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Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Cells, 2021 RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
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Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]
, 1994 To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV +4 more
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Small Nuclear Ribonucleoprotein Remodeling During Catalytic Activation of the Spliceosome [PDF]
Science, 2002 Major structural changes occur in the spliceosome during its activation just before catalyzing the splicing of pre–messenger RNAs (pre-mRNAs). Whereas changes in small nuclear RNA (snRNA) conformation are well documented, little is known about remodeling of small nuclear ribonucleoprotein (snRNP) structures during spliceosome ...
Makarov, E.M. +6 more
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Biology Open, 2014 Spliceosomal small nuclear ribonucleoproteins (snRNPs) are enriched in the Cajal body (CB). Guide RNAs, known as small Cajal body-specific RNAs (scaRNAs), direct modification of the small nuclear RNA (snRNA) component of the snRNP.
Isioma I. Enwerem +5 more
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