Results 41 to 50 of about 139,231 (236)

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. [PDF]

PLoS Biology, 2010
The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies.
Salah Mahmoudi, Sofia Henriksson, Irene Weibrecht, Stephen Smith, Ola Söderberg, Staffan Strömblad, Klas G Wiman, Marianne Farnebo   +7 more
doaj   +1 more source

Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors

Life, 2023
Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined ...
Miroslava Kretova, Tomas Selicky, Ingrid Cipakova, Lubos Cipak   +3 more
doaj   +1 more source

Host Factors interacting with the Pestivirus N terminal protease, Npro are Components of the Ribonucleoprotein Complex [PDF]

, 2014
The viral N-terminal protease N(pro) of pestiviruses counteracts cellular antiviral defenses through inhibition of IRF3. Here we used mass spectrometry to identify a new role for N(pro) through its interaction with over 55 associated proteins, mainly ...
A. Donaszi-Ivanov, Anderson, Aratani, Ariumi, Barsnes, Bauhofer, Beckham, Belsham, Bensaude, Borghese, Chatel-Chaix, Chatel-Chaixa, Costa-Mattioli, Cox, Dixit, Doceul, Eisinger-Mathason, Ettema, Fiebach, Fullam, G. Saalbach, Garcia, Gilks, Gorchakov, Haasnoot, Isken, Jefferson, Johns, Kato, Kok, La Rocca, Lawrence, Leung, Li, Liu, Lloyd, M. Jefferson, Meyers, Müller-McNicoll, Netherton, Onishi, P. P. Powell, Panas, Paranjape, Peterhans, Pichlmair, Piotrowska, Robb, Rümenapf, S. Pollen, Sadler, Saunders, Schröder, Szymanski, T. Dalmay, Taylor, Tetsuka, Tetsuka, Tratschin, White, White, Zhang, Zögg   +62 more
core   +1 more source

Coilin Can Form a Complex with the U7 Small Nuclear Ribonucleoprotein [PDF]

Molecular Biology of the Cell, 1998
Coiled bodies (CBs) in the amphibian oocyte nucleus are spherical structures up to 10 μm or more in diameter, much larger than their somatic counterparts, which rarely exceed 1 μm. Oocyte CBs may have smaller granules attached to their surface or embedded within them, which are identical in structure and composition to the many hundreds of B ...
Joseph G. Gall, Michel Bellini
openaire   +3 more sources

Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis

Biology Open, 2014
Spliceosomal small nuclear ribonucleoproteins (snRNPs) are enriched in the Cajal body (CB). Guide RNAs, known as small Cajal body-specific RNAs (scaRNAs), direct modification of the small nuclear RNA (snRNA) component of the snRNP.
Isioma I. Enwerem, Venkatramreddy Velma, Hanna J. Broome, Marija Kuna, Rowshan A. Begum, Michael D. Hebert   +5 more
doaj   +1 more source

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer

Cells, 2021
RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
doaj   +1 more source

The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases

Frontiers in Molecular Biosciences, 2020
The motor neurodegenerative disease spinal muscular atrophy (SMA) is caused by alterations of the survival motor neuron 1 (SMN1) gene involved in RNA metabolism.
Delphine Sapaly, Perrine Delers, Jennifer Coridon, Badih Salman, Franck Letourneur, Florent Dumont, Suzie Lefebvre   +6 more
doaj   +1 more source

The Cajal body and the nucleolus : “in a relationship” or “it's complicated”? [PDF]

, 2016
From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy.
Sleeman, Judith E., Trinkle-Mulcahy, Laura   +1 more
core   +1 more source

Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core [PDF]

Acta Crystallographica Section D Structural Biology, 2017
U6 small nuclear RNA (snRNA) is a key component of the active site of the spliceosome, a large ribonucleoprotein complex that catalyzes the splicing of precursor messenger RNA. Prior to its incorporation into the spliceosome, U6 is bound by the protein Prp24, which facilitates unwinding of the U6 internal stem-loop (ISL) so that it can pair with U4 ...
Eric J. Montemayor, Allison L. Didychuk, Honghong Liao, Panzhou Hu, David A. Brow, Samuel E. Butcher   +5 more
openaire   +3 more sources

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs [PDF]

, 2011
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
Abovich, Andrew Bottrill, Baccon, Batsche, Bedford, Behrens, Behzadnia, Behzadnia, Black, Brow, Campion, Charroux, Charroux, Das, Deckert, Dignam, Donmez, Donmez, Ester, Evgeny M. Makarov, Gozani, Gubitz, Hall, Hartmuth, Hernandez, Ishihama, Jurica, Kao, Kent, Kofler, Konarska, Kuhn, Lin, Luhrmann, Makarova, Makarova, Meister, Michaud, Michaud, Mourelatos, Neubauer, Nicholas Owen, Olga V. Makarova, Otter, Pellizzoni, Pellizzoni, Perkins, Rappsilber, Sharma, Sharma, Stark, Tanackovic, Wahl, Will, Will, Wolf, Wu, Wu, Xu, Young, Yu, Zhang, Zhou, Zillmann   +63 more
core   +2 more sources