Results 61 to 70 of about 86,105 (313)

Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis

open access: yesFrontiers in Microbiology, 2018
Multidrug-resistant tuberculosis (TB), defined as TB resistant to the two first-line drugs, isoniazid and rifampin, is a serious challenge to global TB eradication efforts.
Zhihong Xu   +9 more
doaj   +1 more source

Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis

open access: yesScience Translational Medicine, 2018
PET reveals spatially heterogeneous rifampin brain penetration, which decreases rapidly with treatment during tuberculous meningitis. TB on the brain Children and immunodeficient individuals are especially prone to tuberculosis infections in the brain ...
E. Tucker   +19 more
semanticscholar   +1 more source

Investigation of Rifampin Serum Levels in Patients Diagnosed with Tuberculosis Treated with the Drug Regimen Mazandaran, 2020-2021 [PDF]

open access: yesJournal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Tuberculosis is one of the leading causes of death from infectious diseases worldwide. Rifampin, a drug used to treat tuberculosis, has recently come under the spotlight.
Lotfollah Davoodi   +3 more
doaj  

Adequacy of Rifampin Absorption after Jejunostomy Tube Administration [PDF]

open access: yes, 2016
It is not always possible to administer antituberculosis pharmacotherapy orally for reasons that may be a direct consequence of tuberculosis itself. To our knowledge, no published literature is available regarding antituberculosis drug absorption via ...
Acocella   +24 more
core   +1 more source

How Well Do Routine Molecular Diagnostics Detect Rifampin Heteroresistance in Mycobacterium tuberculosis?

open access: yesJournal of Clinical Microbiology, 2019
Rifampin heteroresistance—where rifampin-resistant and -susceptible tuberculosis (TB) bacilli coexist—may result in failed standard TB treatment and potential spread of rifampin-resistant strains.
K. C. Ng   +6 more
semanticscholar   +1 more source

Evaluation of Potential Effects of CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Fruquintinib in Healthy Subjects

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Cytochrome P450 (CYP) 3A plays a significant role in fruquintinib metabolism in vitro. This 2‐part, 2‐period fixed‐sequence study investigated the impact of CYP3A inhibition (itraconazole) and CYP3A induction (rifampin) on the pharmacokinetics (PK) of fruquintinib and M11, its main metabolite.
Martha Gonzalez   +5 more
wiley   +1 more source

Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials. [PDF]

open access: yes, 2017
Rifapentine is a highly active antituberculosis antibiotic with treatment-shortening potential; however, exposure-response relations and the dose needed for maximal bactericidal activity have not been established.
Dooley, KE   +12 more
core   +1 more source

Effects of Exogenous Yeast and Bacteria on the Microbial Population Dynamics and Outcomes of Olive Fermentations. [PDF]

open access: yes, 2017
In this study, we examined Sicilian-style green olive fermentations upon the addition of Saccharomyces cerevisiae UCDFST 09-448 and/or Pichia kudriazevii UCDFST09-427 or the lactic acid bacteria (LAB) Lactobacillus plantarum AJ11R and Leuconostoc ...
Charlotte Tyler   +9 more
core   +2 more sources

ERS Special Article. Efficacy and Safety of High‐Dose Rifampin in Pulmonary Tuberculosis. A Randomized Controlled Trial

open access: yesAmerican Journal of Respiratory and Critical Care Medicine, 2018
Rationale: We examined whether increased rifampin doses could shorten standard therapy for tuberculosis without increased toxicity. Objectives: To assess the differences across three daily oral doses of rifampin in change in elimination rate of ...
G. Velásquez   +15 more
semanticscholar   +1 more source

Magnetic Layered Double Hydroxide Nanocomposites: Synthesis, Catalytic Performances, Environmental and Biological Applications

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review involves a comprehensive study on the diverse applications of the magnetic layered double hydroxides (LDHs) including their catalytic performances, as well as, environmental and biological functions. Moreover, different strategies utilized for the synthesis of LDH‐based composites are described.
Mohammad Mavvaji   +2 more
wiley   +1 more source

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