Results 51 to 60 of about 841,194 (353)

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Ring closing reaction in diarylethene captured by femtosecond electron crystallography [PDF]

, 2013
The photoinduced ring-closing reaction in diarylethene, which serves as a model system for understanding reactive crossings through conical intersections, was directly observed with atomic resolution using femtosecond electron diffraction.
Asano Y., Bertarelli C., Boggio-Pasqua M., Carole A. Morrison, Cheng Lu, Chergui M., Clark S. J., Collet E., Coppens P., Dudek R. C., Dwyer J. R., Eichberger M., Erasmus N., Ern J., Ern J., Ern J., Ernstorfer R., Fritz D. M., Gao M., Gao M., Grimme S., Hallmann J., Han T.-R. T., Hania P. R., Hania P. R., Harb M., Harb M., Hubert Jean-Ruel, Ihee H., Irie M., Irie M., Jean-Ruel H., Kobatake S., Kochman M. A., Lai Chung Liu, Meng Gao, Michal A. Kochman, Miyasaka H., Miyasaka H., Miyasaka H., Morimoto M., Okabe C., Owrutsky J. C., Perdew J. P., Poulin P. R., R. J. Dwayne Miller, Ryan R. Cooney, Schotte F., Sciaini G., Sciaini G., Shim S., Siwick B. J., Srinivasan R., Tamai N., Tani K., Techert S., Tian H., Uchida K., Vorontsov I. I.   +58 more
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

From lithium to sodium: cell chemistry of room temperature sodium–air and sodium–sulfur batteries

Beilstein Journal of Nanotechnology, 2015
Research devoted to room temperature lithium–sulfur (Li/S8) and lithium–oxygen (Li/O2) batteries has significantly increased over the past ten years. The race to develop such cell systems is mainly motivated by the very high theoretical energy density ...
Philipp Adelhelm, Pascal Hartmann, Conrad L. Bender, Martin Busche, Christine Eufinger, Juergen Janek   +5 more
doaj   +1 more source

Recent Advances in Iridium-Catalyzed Asymmetric Hydrogenation: New Catalysts, Substrates and Applications in Total Synthesis

CHIMIA, 2012
Iridium-catalyzed asymmetric hydrogenation has emerged as a highly efficient method for the synthesis of enantiomerically pure compounds. This account summarizes our recent efforts in this field.
Adnan Ganić, Denise Rageot, Lars Tröndlin, Andreas Pfaltz   +3 more
doaj   +1 more source

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold [PDF]

, 2018
Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector Gli1 have thus emerged ...
Bruno Botta, Cinzia Ingallina, Elisa De Paolis, Flavia Bernardi, Francesca Ghirga, Isabella Romeo, Lucia Di Marcotullio, Mattia Mori, Miriam Caimano, Paola Infante, Romina Alfonsi, Sara Toscano, Simone Berardozzi   +12 more
core   +2 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Photochemistry Meets Porous Organic Cages

CHIMIA, 2021
Chemistry of porous organic cages has developed in the past decade as an alternative to the wellknown nanoporous materials based on extended networks, such as metal organic frameworks (MOFs) or covalent organic frameworks (COFs).
Hsin-Hua Huang, Tomáš Šolomek
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Mass Spectrometry Imaging Disclosed Spatial Distribution of Defense-Related Metabolites in Triticum spp.

Metabolites, 2022
Fusarium Head Blight is the most common fungal disease that strongly affects Triticum spp., reducing crop yield and leading to the accumulation of toxic metabolites.
Laura Righetti, Sven Gottwald, Sara Tortorella, Bernhard Spengler, Dhaka Ram Bhandari   +4 more
doaj   +1 more source