Results 61 to 70 of about 2,301,251 (349)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Epoxide Syntheses and Ring-Opening Reactions in Drug Development

, 2020
This review concentrates on success stories from the synthesis of approved medicines and drug candidates using epoxide chemistry in the development of robust and efficient syntheses at large scale. The focus is on those parts of each synthesis related to
Fotini Moschona, Ioanna Savvopoulou, Maria Tsitopoulou, D. Tataraki, G. Rassias   +4 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Anaerobic Digestion of Laminaria japonica Waste from Industrial Production Residues in Laboratory- and Pilot-Scale

Marine Drugs, 2015
The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the
Yann Nicolas Barbot, Claudia Thomsen, Laurenz Thomsen, Roland Benz   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Dualism of Remarkable Magnesium Ion Conduction with Low Activation Energy over a Wide Temperature Range versus Limited Stability of the Hybrid Composite Electrolyte Mg‐MOF‐74/MgX2/Propylene Carbonate

Advanced Energy & Sustainability Research
A metal–organic framework (MOF) quasi‐solid‐state Mg2+‐ion conductor is prepared with a conductivity of 0.6 × 10−4 S cm−1 already at room temperature. Mg‐MOF‐74 acts as host for MgX2 (X = Cl−, Br−, BF4−) dissolved in propylene carbonate, leading to dry ...
Ruben Maile, Zhixuan Wei, Andreas Johannes Achazi, Kangli Wang, Pascal Henkel, Doreen Mollenhauer, Jürgen Janek, Klaus Müller‐Buschbaum   +7 more
doaj   +1 more source

Thermo-Acidic Pretreatment of Beach Macroalgae from Rügen to Optimize Biomethane Production—Double Benefit with Simultaneous Bioenergy Production and Improvement of Local Beach and Waste Management

Marine Drugs, 2015
Eutrophication is a phenomenon which can rapidly generate masses of marine macroalgae, particularly in areas with high nutrient pollution. Washed ashore, this biomass impairs coastal tourism and negatively affects the coastal ecosystem. The present study
Yann Nicolas Barbot, Laurenz Thomsen, Roland Benz   +2 more
doaj   +1 more source

Exploring the frontiers of condensed-phase chemistry with a general reactive machine learning potential

Nature Chemistry
Atomistic simulation has a broad range of applications from drug design to materials discovery. Machine learning interatomic potentials (MLIPs) have become an efficient alternative to computationally expensive ab initio simulations.
Shuhao Zhang, Małgorzata Z. Makoś, Ryan B Jadrich, E. Kraka, Kipton Barros, B. Nebgen, Sergei Tretiak, O. Isayev, N. Lubbers, Richard A. Messerly, Justin S. Smith   +10 more
semanticscholar   +1 more source