Results 191 to 200 of about 18,020 (210)
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Genetic Regulation of RIPK1 and Necroptosis
Annual Review of Genetics, 2021The receptor-interacting protein kinase 1 (RIPK1) is recognized as a master upstream regulator that controls cell survival and inflammatory signaling as well as multiple cell death pathways, including apoptosis and necroptosis. The activation of RIPK1 kinase is extensively modulated by ubiquitination and phosphorylation, which are mediated by multiple
Daichao, Xu, Chengyu, Zou, Junying, Yuan
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RIPK1 and RIPK3 in antibacterial defence
Biochemical Society Transactions, 2022Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by either driving inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis,
Hui Wen Yeap, Kaiwen W. Chen
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RIPK1 ubiquitination: Evidence, correlations and the undefined
Seminars in Cell & Developmental Biology, 2021Over the last two decades the mechanisms that underpin cell survival and cell death have been intensively studied. One molecule in particular, Receptor Interacting Protein Kinase 1 (RIPK1), has gained interest due to the ability to function upstream of both NF-κB signaling and caspase-dependent and -independent cell death.
Daniel S, Simpson +2 more
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RIPK1 targeting protects against obesity and atherosclerosis
Trends in Endocrinology & Metabolism, 2021Unhealthy lifestyles and dietary habits often lead to diet-associated inflammatory diseases such as obesity and atherosclerosis. Recent studies have provided novel insight into the role of RIPK1 in inflammation and metabolism. RIPK1 silencing can reduce diet-induced obesity, nonalcoholic fatty liver disease (NAFLD), and atherosclerosis by reducing ...
Yahya, Sohrabi, Holger, Reinecke
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Repurposing crizotinib to target RIPK1-dependent cell death
International Immunology, 2022Abstract Receptor-interacting protein kinase 1 (RIPK1) has emerged as a key regulator of cell death and inflammation, which are implicated in the pathogenesis of many inflammatory and degenerative diseases. RIPK1 is therefore a putative therapeutic target in many of these diseases.
Yajie Yu +11 more
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Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs
Trends in Pharmacological Sciences, 2020The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates prosurvival signaling and inflammatory gene expression, while its kinase activity mediates both apoptosis and necroptosis; the latter involving RIPK3 kinase activity.
Martens, Sofie +4 more
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RIPK1 inhibits ZBP1-driven necroptosis during development
Nature, 2016Receptor-interacting protein kinase 1 (RIPK1) promotes cell survival-mice lacking RIPK1 die perinatally, exhibiting aberrant caspase-8-dependent apoptosis and mixed lineage kinase-like (MLKL)-dependent necroptosis. However, mice expressing catalytically inactive RIPK1 are viable, and an ill-defined pro-survival function for the RIPK1 scaffold has ...
Kim, Newton +12 more
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TBK1 inhibition unleashes RIPK1, resensitizing tumors to immunotherapy
Trends in Immunology, 2023Resistance mechanisms have curbed the potential of immune checkpoint blockade (ICB) therapies. Understanding mechanisms that contribute to this resistance should reveal new targets for combinatorial therapy. Tank-binding kinase 1 (TBK1) represents such a target.
Michelle A. Kelliher +1 more
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RIPK1 Promotes Intrinsic and Extrinsic Resistance to Immunotherapy
Cancer Discovery, 2022Abstract RIPK1 loss enhances immunotherapy by reshaping immune populations and poising tumor cells for killing.
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A BAF-fling connection to RIPK1
Cell Research, 2022Jessica M. Gullett +1 more
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