Results 81 to 90 of about 15,574 (187)

Downregulation of Ripk1 and Nsf mediated by CRISPR-CasRx ameliorates stroke volume and neurological deficits after ischemia stroke in mice

Frontiers in Aging Neuroscience
Necroptosis is implicated in the pathogenesis of ischemic stroke. However, the mechanism underlying the sequential recruitment of receptor-interacting protein kinase 1 (RIPK1) and N-ethylmaleimide-sensitive fusion ATPase (NSF) in initiating necroptosis ...
Xincheng Song, Xincheng Song, Yang Lan, Shuang Lv, Yuye Wang, Leian Chen, Tao Lu, Fei Liu, Dantao Peng, Dantao Peng, Dantao Peng   +10 more
doaj   +1 more source

Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway

, 2019
Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells during early acute pancreatitis (AP), which ...
Yuan Ma, Xi-na Li, Peng-yu Duan, Wang-jun Zhang, Liang Ji, Le Li, Gang Wang, Feng-zhi Qu, Ji-sheng Hu, Xiao-yu Guo, Fan Xiao, Bei Sun   +11 more
core   +1 more source

Inhibition of Necroptosis in Acute Pancreatitis: Screening for RIPK1 Inhibitors

, 2022
This work utilizes the anthraquinone (AQ) database to identify potential inhibitors of the RIPK1 protein for developing medicines targeting AP-associated necroptosis.
Ping Wu, Yan Liu, Hailong Chen, Yin Wang, Yalan Luo, Jiaqi Yao, Xiaojun Liu, Qingping Wen   +7 more
core   +1 more source

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

Scientific Reports, 2017
Hepatocyte death is a central event during liver disease progression, in which immune cells play key roles by activating members of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), including TNFR1 (TNFRSF1A), Fas (TNFRSF6) and TRAIL-R2 (TNFRSF10B)
Aveline Filliol, Muhammad Farooq, Claire Piquet-Pellorce, Valentine Genet, Marie-Thérèse Dimanche-Boitrel, Peter Vandenabeele, Mathieu J. M. Bertrand, Michel Samson, Jacques Le Seyec   +8 more
doaj   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

RIPK1 and RIPK3 - emerging targets in cancer?

, 2018
RIPK1 and RIPK3 are homologous Ser/Thr kinases, which act in concert within the necrosome complexes to initiate a sub-type of regulated necrosis, termed necroptosis.
Suraj Shah, Kerem Gurol, Alexei Degterev
core   +1 more source

Primidone blocks RIPK1-driven cell death and inflammation

, 2020
The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy of RIPK1-dependent organ damage in stroke,
Schunk, Domagoj, Charlotte Flüh, Eileen Dahlke, Wilson, R, Benedikt Kolbrink, Moerke, C, Dahlke, Eileen, Domagoj Schunk, Pascal Meier, Dahlke, E, Ramos Garcia, Laura, Philipp Doldi, Doldi, P, Doldi, Philipp, Riebeling, T, Schunk, D, Krautwald, Stefan, Kunzendorf, Ulrich, Theilig, F, Tyczynski, Bartosz, Bartosz Tyczynski, Lühder, F, Rebecca Wilson, Fred Lühder, Stefan Krautwald, Wilson, Rebecca, Friederike Michels, Kribben, Andreas, Kribben, A, Caroline Moerke, Kolbrink, B, Riebeling, Theresa, Michels, F, Kunzendorf, U, Flüh, Charlotte, Jamal, K, Laura Ramos Garcia, Kunzah Jamal, Ulrich Kunzendorf, Jamal, Kunzah, Krautwald, S, Meier, Pascal, Andreas Kribben, Theresa Riebeling, Franziska Theilig, Tyczynski, B, Lühder, Fred, Moerke, Caroline, Friedrich Alexander von Samson-Himmelstjerna, Flüh, C, Ramos Garcia, L, Michels, Friederike, von Samson-Himmelstjerna, FA, Kolbrink, Benedikt, Theilig, Franziska, von Samson-Himmelstjerna, Friedrich Alexander, Meier, P   +56 more
core   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

, 2018
Stimulation of cells with TNFα leads to the formation of the TNF-R1 signaling complex (TNF-RSC) to mediate downstream cellular fate decision. Activation of the TNF-RSC is modulated by different types of ubiquitination and may lead to cell death ...
Wei, R (via Mendeley Data), Wei, Ran
core   +1 more source

Retrovirology / HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2 [PDF]

, 2015
Background: HIV-1 protease (PR) is essential for viral infectivity as it cleaves Gag and Gag-Pol polyprotein precursors during viral maturation. Recent evidence suggests that cellular proteins can also be cleaved by PR, perhaps representing an important ...
Chanda, Sumit K., Wagner, Roland N., Reed, John C.   +2 more
core   +1 more source