Results 91 to 100 of about 3,236 (190)

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

, 2018
Stimulation of cells with TNFα leads to the formation of the TNF-R1 signaling complex (TNF-RSC) to mediate downstream cellular fate decision. Activation of the TNF-RSC is modulated by different types of ubiquitination and may lead to cell death ...
Wei, R (via Mendeley Data)
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Monitoring RIPK1 phosphorylation in the TNFR1 signaling complex

, 2018
Receptor-interacting protein kinase 1 (RIPK1) is a component of the TNFR1 signaling complex (also known as complex I or TNFR-SC), where its ubiquitylation by cIAP1/2 and LUBAC serves to initiate prosurvival and proinflammatory responses through ...
Yves Dondelinger, Dondelinger, Yves, Dario Priem, Mathieu J. M. Bertrand, Priem, Dario, Bertrand, Mathieu   +5 more
core   +1 more source

A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1

Nature Communications
Tumor necrosis factor (TNF)-induced RIPK1-mediated cell death is implicated in various human diseases. However, the mechanisms RIPK1-mediated cell death is regulated by metabolic processes remain unclear.
Tianhao Zou, Ran Liu, Gengqiao Wang, Guoliang Wang, Zhengting Jiang, Chuanzheng Wang, Weimin Wang, Mao Cai, Shuhua Zhang, Huan Cao, Di Zhang, Xueling Wang, Shenghe Deng, Tongxi Li, Jinyang Gu   +14 more
doaj   +1 more source

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

Scientific Reports, 2017
Hepatocyte death is a central event during liver disease progression, in which immune cells play key roles by activating members of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), including TNFR1 (TNFRSF1A), Fas (TNFRSF6) and TRAIL-R2 (TNFRSF10B)
Aveline Filliol, Muhammad Farooq, Claire Piquet-Pellorce, Valentine Genet, Marie-Thérèse Dimanche-Boitrel, Peter Vandenabeele, Mathieu J. M. Bertrand, Michel Samson, Jacques Le Seyec   +8 more
doaj   +1 more source

Association of RIPK1 and RIPK2 Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Han Population [PDF]

Shuang Lv,1 Yiming Li,2 Bojian Sun,1 Yu Jing,1 Xing Wang,3 Zhanqing Gu,1 Bailiang Wang,4 Cheng Xiao3 1Department of Rheumatology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of ...
Jing Y, Li Y, Wang B, Sun B, Lv S, Gu Z, Wang X, Xiao C   +7 more
core  

Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

Nature Communications, 2020
RIPK1 is a critical kinase which mediates necroptosis, apoptosis and inflammation. Regulation of RIPK1 by ubiquitination is being intensively investigated.
Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan, Junying Yuan   +12 more
doaj   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

, 2017
International audienceHighlights d RIPK1 ablation induces TNF-mediated hepatocyte apoptosis without affecting NF-kB d Loss of RIPK1 leads to proteasomal TRAF2 degradation in a kinase-independent manner d RIPK1 and TRAF2 act together to prevent ...
Panayotova-Dimitrova, Diana, Longerich, Thomas, Büchler, Markus, W, Schneider, Anne T., Feoktistova, Maria, Lüdde, Tom, Nachbur, Ueli, Neumann, Ulf Peter, Zucman-Rossi, Jessica, Loosen, Sven, Benz, Fabian, Luedde, Mark, Neumann, Ulf, P, Leverkus, Martin, Schemmer, Peter, Roy, Sanchari, Vucur, Mihael, Trautwein, Christian, Loosen, Sven, H, Preisinger, Christian, Tolba, Rene, Roderburg, Christoph, Tacke, Frank, Gautheron, Jérémie, Tolba, René H., Schneider, Anne, T, Luedde, Tom, Büchler, Markus W.   +27 more
core   +1 more source

Primidone blocks RIPK1-driven cell death and inflammation

, 2020
The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy of RIPK1-dependent organ damage in stroke,
Schunk, Domagoj, Charlotte Flüh, Eileen Dahlke, Wilson, R, Benedikt Kolbrink, Moerke, C, Dahlke, Eileen, Domagoj Schunk, Pascal Meier, Dahlke, E, Ramos Garcia, Laura, Philipp Doldi, Doldi, P, Doldi, Philipp, Riebeling, T, Schunk, D, Krautwald, Stefan, Kunzendorf, Ulrich, Theilig, F, Tyczynski, Bartosz, Bartosz Tyczynski, Lühder, F, Rebecca Wilson, Fred Lühder, Stefan Krautwald, Wilson, Rebecca, Friederike Michels, Kribben, Andreas, Kribben, A, Caroline Moerke, Kolbrink, B, Riebeling, Theresa, Michels, F, Kunzendorf, U, Flüh, Charlotte, Jamal, K, Laura Ramos Garcia, Kunzah Jamal, Ulrich Kunzendorf, Jamal, Kunzah, Krautwald, S, Meier, Pascal, Andreas Kribben, Theresa Riebeling, Franziska Theilig, Tyczynski, B, Lühder, Fred, Moerke, Caroline, Friedrich Alexander von Samson-Himmelstjerna, Flüh, C, Ramos Garcia, L, Michels, Friederike, von Samson-Himmelstjerna, FA, Kolbrink, Benedikt, Theilig, Franziska, von Samson-Himmelstjerna, Friedrich Alexander, Meier, P   +56 more
core   +1 more source