Results 111 to 120 of about 15,574 (187)

RIPK1 at the interface between cell death and immunity

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that co-ordinates cell survival, inflammation, and immunogenic cell death (ICD).
Mannion, J
core   +1 more source

Bioinformatics analyses reveal the role of RIPK1 in clear cell renal cell carcinoma

BMC Cancer
Background Receptor interacting protein kinase 1 (RIPK1) is crucial in the regulation of apoptosis; however, its significance in clear cell renal cell carcinoma (ccRCC) is not well understood. Methods Utilizing data collected from public databases, RIPK1
Daocheng Fang, Yuanyuan Hu, Shuangquan Sun, Hui Wen, Jie Fan   +4 more
doaj   +1 more source

RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8

Cell Death Discovery
RIPK1 (Receptor-interacting serine/threonine-protein kinase 1) is fundamental in regulating cell proliferation, programmed cell death, and inflammation.
Ning Nan, Hong Hu, Xinxin Zhu, Jia Liu, Feiyang Yuan, Zhijie Li, Huayi Wang   +6 more
doaj   +1 more source

RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression

Cell Communication and Signaling
Background Depression is often linked to inflammation in the brain. Researchers have been exploring ways to reduce this inflammation to improve depression symptoms.
Qichao Gong, Tahir Ali, Yue Hu, Ruyan Gao, Shengnan Mou, Yanhua Luo, Canyu Yang, Axiang Li, Tao Li, Liang Liang Hao, Liufang He, Xiaoming Yu, Shupeng Li   +12 more
doaj   +1 more source

HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death. [PDF]

Nat Struct Mol Biol
Lu H, Du T, Li L, Cao D, Li K, Liu L, Li R, Yu X, Hou S, Wang X, Shi M, Liu Y, Ma F, Chen S, Walczak H, He S.   +15 more
europepmc   +1 more source

RIPK1 in Alzheimer's Disease: A Context-Dependent Signaling Hub Linking Aβ, Tau, Neuroinflammation, and Regulated Cell Death. [PDF]

Cells
Caccamo A, Lanza M, Casili G, Oddo S.
europepmc   +1 more source

One adaptor, multiple outcomes: decoding TRIFosome heterogeneity. [PDF]

Biochem Soc Trans
Suresh P, Zhang YP, Bryant C, Klenerman D.   +3 more
europepmc   +1 more source

Suppression of Calpain Attenuates Coxsackievirus B3-Induced Myocarditis by Regulating RIPK1/RIPK3/MLKL Pathway. [PDF]

J Cardiovasc Transl Res
Liu Y, Wang Y, Liu G, Yi F, Che D, Chen Z, Zou Y, Chen R.   +7 more
europepmc   +1 more source

Regulation of RIPK1 Dependent Apoptosis and Necroptosis

, 2018
RIPK1 is a Ser/Thr kinase critically involved in mediating multiple signaling pathways activated by TNFa. When cells are stimulated by TNFa, RIPK1 is rapidly recruited to the intracellular domain of TNFR1 to form the TNF-RSC (TNF receptor signaling ...
Amin, Palak Prakash
core  

Lysosomal-stress-driven cargo-fate switching between autophagic degradation and small extracellular vesicle release in triple-negative breast cancer: a hypothesis and theory article. [PDF]

Front Oncol
Liu Y, Qi G, Wang A, Hu F.
europepmc   +1 more source