Results 141 to 150 of about 3,236 (190)

Intercellular propagation of RIPK1/RIPK3 amyloid fibrils

Proceedings of the National Academy of Sciences
The canonical necrosome formed by receptor-interacting protein kinase 1 (RIPK1) and RIPK3 is a functional amyloid fibril structure critical to intracellularly drive necroptosis. Since necroptosis leads to the release of intracellular content, the fate of RIPK1/RIPK3 fibrils after necroptotic cell death has not been investigated.
Yeyang Ma, Qiuyuan Zhang, Dekang Li, Kun Zhao, Zefei Li, Yuan Liu, Chu Wang, Bo Sun, Dan Li, Junying Yuan, Cong Liu   +10 more
openaire   +2 more sources

Salvianolic Acid B Inhibits Ferroptosis in Acute Lung Injury: Network Analysis and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT This current study aimed to decipher the anti‐inflammatory, anti‐ferroptosis and pronounced lung‐protective activities of Salvianolic acid B (Sal B) by integrating network pharmacology and experimental confirmation across multiple aspects. The optimal target protein and the relevant molecular mechanisms for Sal B in the context of ALI were ...
Hejun Gao, Renhui Xiong, Na Yue, Jiaxin Wang, Shouyuan Tian   +4 more
wiley   +1 more source

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3 [PDF]

Cell Death & Differentiation, 2018
Annibaldi, A, Meier, P
openaire   +3 more sources

RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression

Cell Communication and Signaling
Background Depression is often linked to inflammation in the brain. Researchers have been exploring ways to reduce this inflammation to improve depression symptoms.
Qichao Gong, Tahir Ali, Yue Hu, Ruyan Gao, Shengnan Mou, Yanhua Luo, Canyu Yang, Axiang Li, Tao Li, Liang Liang Hao, Liufang He, Xiaoming Yu, Shupeng Li   +12 more
doaj   +1 more source

RIPK1 Inhibitor GSK3145095 [PDF]

, 2020
openaire   +1 more source

RIPK1 wt Allele [PDF]

, 2020
openaire   +1 more source

Primary immunodeficiency reveals importance of RIPK1 [PDF]

Nature Reviews Rheumatology, 2018
openaire   +2 more sources

RIPK1 at the interface between cell death and immunity

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that co-ordinates cell survival, inflammation, and immunogenic cell death (ICD).
Mannion, J
core   +1 more source

RIPK1 protects epithelial cells [PDF]

Nature Reviews Molecular Cell Biology, 2014
openaire   +1 more source

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RIPK1 ubiquitination: Evidence, correlations and the undefined

Seminars in Cell and Developmental Biology, 2021
Over the last two decades the mechanisms that underpin cell survival and cell death have been intensively studied. One molecule in particular, Receptor Interacting Protein Kinase 1 (RIPK1), has gained interest due to the ability to function upstream of both NF-κB signaling and caspase-dependent and -independent cell death.
Rebecca Feltham, Daniel S Simpson
exaly   +3 more sources