Results 161 to 170 of about 15,574 (187)

RIPK 1 in Alzheimer's Disease: Research Progress Integrating Pathogenesis on Necroptosis-Related Neuroinflammation, and Potential Therapeutic Strategies. [PDF]

Biomedicines
Toklucu ES, Shen S, Wang C, Zhang C.
europepmc   +1 more source

Decoding the crosstalk: interplay between macrophage programmed cell death networks and cholesterol efflux. [PDF]

Front Cardiovasc Med
Bian Y, Hu X.
europepmc   +1 more source

Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1. [PDF]

EMBO Rep
Lu F, Tang L, Tian Z, Tian J, Fu Y, Gao A, Dong H, Chen J, Lu H, Kim C, Lai D, Zhou C, He J, Tou J, Lin J, Jiao H.   +15 more
europepmc   +1 more source

Endothelial-specific RIPK1 K376 mutation triggers kinase hyperactivation and embryonic lethality. [PDF]

Genes Dis
Wu Z, Wang L, Wu X, Li M, Zhang H.
europepmc   +1 more source

Targeting AIF to trigger RIPKs/MLKL necroptosis: a disulfiram-based strategy to reverse paclitaxel resistance in ovarian cancer. [PDF]

Cell Commun Signal
Li J, Zhou W, Tang H, Zhu W, He M, Xiong Q, Han Z, Lin X, Chen J, He X, Chen M, Yang Y, Meng X, Ma L, Li F, Wang J, Zhang K.   +16 more
europepmc   +1 more source

LILRB4 Attenuates Ischemic Brain Injury by Inhibiting Microglial Necroptosis via a RIPK3-Dependent Mechanism. [PDF]

Glia
Hu J, Zhang M, Liu P, Chen Y, Meng H, Xia S, Bao X, Xu Y, Chen Y.   +8 more
europepmc   +1 more source

Death-Domain Dimerization-Mediated Activation of RIPK1 Controls Necroptosis and RIPK1-Dependent Apoptosis

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance While the critical role of RIPK1 kinase activity in mediating necroptosis and RIPK1-dependent apoptosis has been established, we still know little about how the nonkinase domains of RIPK1 regulate its kinase activity.
Huibing Wang, Zhen Liu, Huyan Meng
exaly   +2 more sources

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death [PDF]

Molecular Cell, 2017
TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase MK2, thereby promoting ...
Rebecca Feltham, Chun Kim, Najoua Lalaoui   +2 more
exaly   +2 more sources

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

Trends in Pharmacological Sciences, 2020
: The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates prosurvival signaling and inflammatory gene expression, while its kinase activity mediates both apoptosis and necroptosis; the latter involving RIPK3 kinase activity ...
Peter Vandenabeele, Koen Augustyns, Peter Vandenabeele   +2 more
exaly   +2 more sources