Results 151 to 160 of about 3,236 (190)
Enigmatic role of RIPK1 in leukemia
, 2023 Introduction Cell survival, inflammation and death are essential physiological events for maintaining cellular homeostasis and for preventing disease, especially cancer. These processes may be regulated by receptor-interacting protein kinase 1 (RIPK1), whose activity depends on post-translational modifications [1].
Laura Della Torre +4 more
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RIPK1 and RIPK3 in antibacterial defence
Biochemical Society Transactions, 2022Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by either driving inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis,
Hui Wen Yeap, Kaiwen W. Chen
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Genetic Regulation of RIPK1 and Necroptosis
Annual Review of Genetics, 2021The receptor-interacting protein kinase 1 (RIPK1) is recognized as a master upstream regulator that controls cell survival and inflammatory signaling as well as multiple cell death pathways, including apoptosis and necroptosis. The activation of RIPK1 kinase is extensively modulated by ubiquitination and phosphorylation, which are mediated by multiple
Daichao, Xu, Chengyu, Zou, Junying, Yuan
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RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events
Trends in Cell Biology, 2020 The serine/threonine kinase RIPK1 has emerged as a crucial component of the inflammatory response activated downstream of several immune receptors, where it paradoxically functions as a scaffold to protect the cell from death or instead as an active ...
Mathieu Jm Bertrand +2 more
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RIPK1 in necroptosis and recent progress in related pharmaceutics [PDF]
Frontiers in ImmunologyNecroptosis is a programmed form of cell death. Receptor-interacting serine/threonine protein kinase l (RIPK1) is a crucial protein kinase that regulates the necroptosis pathway.
Kunhou Yao
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RIPK1: A Promising Target for Intervention Neuroinflammation
Journal of Neuroimmune PharmacologyNecroptosis is a novel mode of cell death that differs from traditional apoptosis, characterized by distinct molecular mechanisms and physiopathological features. Recent research has increasingly underscored the pivotal role of necroptosis in various neurological diseases, including stroke, Alzheimer's disease and multiple sclerosis.
Feixing, Yan +5 more
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Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
Trends in Cell Biology, 2016 The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway.
Nieves Peltzer +2 more
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RIPK1 Promotes Intrinsic and Extrinsic Resistance to Immunotherapy
Cancer Discovery, 2022Abstract RIPK1 loss enhances immunotherapy by reshaping immune populations and poising tumor cells for killing.
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A BAF-fling connection to RIPK1
Cell Research, 2022Jessica M. Gullett +1 more
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A novel RIPK1 inhibitor attenuates GVHD
Blood, 2023Hill, Geoffrey R., Koyama, Motoko
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